Patents Assigned to Japan Science and Tehcnology Agency
  • Nucleic acid participating in the formation of presenilin-2-gene exon 5-defective splicing variant
    Patent number: 7364847
    Abstract: The present invention provides a means for treatment and/or prevention of a disease caused by aberrant splicing, a neurodegenerative disease represented by Alzheimer's disease, or the like. The present invention relates to a nucleic acid which can be associated with generation of a splice variant that lacks exon 5 of presenilin-2 gene, an inhibitor for inhibiting a binding between protein-nucleic acid caused by aberrant splicing, and a method for screening the inhibitor.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: April 29, 2008
    Assignee: Japan Science and Tehcnology Agency
    Inventors: Masaya Tohyama, Taiichi Katayama, Takayuki Manabe, Kazunori Imaizumi, Yoko Ikeda