Abstract: An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.

Abstract: An object of the invention is to provide a cartilage regenerative material that suppresses infiltration of fibrous soft tissue and brings about satisfactory cartilage regeneration, and a method for producing the cartilage regenerative material. Provided is a cartilage regenerative material including a porous body of a biocompatible polymer and a biocompatible polymer film, in which the porous body contains chondrocytes and cartilage matrix, and the cartilage matrix exists in a region of 10% or more of a region extending from the surface of the transplant face of the porous body to a depth of 150 ?m along the thickness.

Abstract: An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.

Abstract: An inner bag of a cell culture package is enclosed in an outer bag such that a rubber stopper is exposed to the outside. A closed space surrounded by the outer surface of the inner bag and the inner surface of the outer bag is sterile. This allows the outer surface of the inner bag, which is used for containing cell-containing deformable materials, to be maintained in a sterile condition. Since the cell culture package can be sterilized before a cell-containing deformable material is placed therein, the sterilization conditions can be relatively easily determined without considering the influence on the cell-containing deformable material. In addition, a holder allows liquid to pass through the bottom surface and side surface of a recess and the bottom surface and the side surface of a cover.

Abstract: An object of the invention is to provide a cartilage regenerative material that suppresses infiltration of fibrous soft tissue and brings about satisfactory cartilage regeneration, and a method for producing the cartilage regenerative material. Provided is a cartilage regenerative material including a porous body of a biocompatible polymer and a biocompatible polymer film, in which the porous body contains chondrocytes and cartilage matrix, and the cartilage matrix exists in a region of 10% or more of a region extending from the surface of the transplant face of the porous body to a depth of 150 ?m along the thickness.

Abstract: A safety cabinet has a second operation chamber in a first operation chamber and into which clean air is supplied, a second suction opening for sucking in air in the second operation chamber and a portion of the air in the first operation chamber, and a second operation opening part that is provided facing a first operation opening part and communicates the second operation chamber with the first operation chamber. Airflow containment (air barrier) is doubled with respect to the outside of a safety cabinet. In cases where decontamination and disinfection operations are carried out according to the changeover procedures, intensive decontamination and disinfection of the second operation chamber is sufficient, and decontamination and disinfection of the first operation chamber is hardly required. Decontamination and disinfection operations in the changeover procedures and the like can be carried out in a greatly reduced time.

Abstract: A work area is disposed in a conveyance path for cells and has an inlet and an outlet, with a downflow air curtain provided at least at the inlet and the outlet. A conveyor repeatedly performs an operation that moves a placement surface having a culture vessel thereon from the inlet side into the area, moves the placement surface from the outlet side to the outside of the area, and, subsequently, moves back the placement surface to the inlet side. The cleaning device cleans the placement surface during the period from when the conveyor in the work area moves the placement surface to the outside of the area until the conveyor moves back the placement surface to the inlet side of the area.

Abstract: An internal joint cavity expander includes femur-side magnets, tibia-side magnets, and magnetic shield-members. Each femur-side magnet has a plate curved into an arc and fixed to a femur. Each tibia-side magnet has length smaller than the femur-side magnet length and having a plate curved into arc concentric with the femur-side magnet arc. Each tibia-side magnet is fixed to a tibia. The pole on the convex surface of each femur-side magnet is same as the pole on the concave surface corresponding tibia-side magnet. The convex surface of each femur-side magnet faces the concave surface of corresponding tibia-side magnet. Each magnetic shield-member covers the surface of corresponding femur-side magnet and tibia-side magnet facing the skin throughout range in which the femur-side magnet moves relative to the tibia-side magnet. Each magnetic shield-member prevents magnetism of corresponding magnets and from leaking outside without hindering the femur-side magnet movement relative to the tibia-side magnet.

Abstract: An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.

Abstract: A safety cabinet has a second operation chamber in a first operation chamber and into which clean air is supplied, a second suction opening for sucking in air in the second operation chamber and a portion of the air in the first operation chamber, and a second operation opening part that is provided facing a first operation opening part and communicates the second operation chamber with the first operation chamber. Airflow containment (air barrier) is doubled with respect to the outside of a safety cabinet. In cases where decontamination and disinfection operations are carried out according to the changeover procedures, intensive decontamination and disinfection of the second operation chamber is sufficient, and decontamination and disinfection of the first operation chamber is hardly required. Decontamination and disinfection operations in the changeover procedures and the like can be carried out in a greatly reduced time.

Abstract: A cell separation container includes a collection chamber and a tissue holding chamber which are partitioned by a filter. The cell separation container includes a first air pressure adjuster configured to adjust the inflow and outflow of gas in the collection chamber and a second air pressure adjuster configured to adjust the inflow and outflow of gas in the tissue holding chamber. Thus, the inflow and outflow of the outside air and the gases in the collection chamber and the tissue holding chamber can be adjusted. In the cell separation container, switching between holding a treatment liquid in the tissue holding chamber and ejecting a treatment liquid to the collection chamber can be performed by adjusting the inflow and outflow of the outside air and the gas in the connection chamber.

Abstract: An internal joint cavity expander includes femur-side magnets, tibia-side magnets, and magnetic shield-members. Each femur-side magnet has a plate curved into an arc and fixed to a femur. Each tibia-side magnet has length smaller than the femur-side magnet length and having a plate curved into arc concentric with the femur-side magnet arc. Each tibia-side magnet is fixed to a tibia. The pole on the convex surface of each femur-side magnet is same as the pole on the concave surface corresponding tibia-side magnet. The convex surface of each femur-side magnet faces the concave surface of corresponding tibia-side magnet. Each magnetic shield-member covers the surface of corresponding femur-side magnet and tibia-side magnet facing the skin throughout range in which the femur-side magnet moves relative to the tibia-side magnet. Each magnetic shield-member prevents magnetism of corresponding magnets and from leaking outside without hindering the femur-side magnet movement relative to the tibia-side magnet.

Abstract: A work area is disposed in a conveyance path for cells and has an inlet and an outlet, with a downflow air curtain provided at least at the inlet and the outlet. A conveyor repeatedly performs an operation that moves a placement surface having a culture vessel thereon from the inlet side into the area, moves the placement surface from the outlet side to the outside of the area, and, subsequently, moves back the placement surface to the inlet side. The cleaning device cleans the placement surface during the period from when the conveyor in the work area moves the placement surface to the outside of the area until the conveyor moves back the placement surface to the inlet side of the area.

Abstract: An inner bag of a cell culture package is enclosed in an outer bag such that a rubber stopper is exposed to the outside. A closed space surrounded by the outer surface of the inner bag and the inner surface of the outer bag is sterile. This allows the outer surface of the inner bag, which is used for containing cell-containing deformable materials, to be maintained in a sterile condition. Since the cell culture package can be sterilized before a cell-containing deformable material is placed therein, the sterilization conditions can be relatively easily determined without considering the influence on the cell-containing deformable material. In addition, a holder allows liquid to pass through the bottom surface and side surface of a recess and the bottom surface and the side surface of a cover.

Abstract: Artificial dermis for transplantation includes a wound contact layer that includes a porous sheet consisting of a biodegradable material, the porous sheet satisfying the following Equation, Equation: X2/X1?0.8. In the porous sheet, when a line parallel to a wound contact face and a line perpendicular to a wound contact face of equal length are drawn, X1 represents a number of points of intersection between the line parallel to the wound contact face and pore walls; and X2 represents a number of points of intersection between the line perpendicular to the wound contact face and pore walls.

Abstract: A cell separation container includes a collection chamber and a tissue holding chamber which are partitioned by a filter. The cell separation container includes a first air pressure adjuster configured to adjust the inflow and outflow of gas in the collection chamber and a second air pressure adjuster configured to adjust the inflow and outflow of gas in the tissue holding chamber. Thus, the inflow and outflow of the outside air and the gases in the collection chamber and the tissue holding chamber can be adjusted. In the cell separation container, switching between holding a treatment liquid in the tissue holding chamber and ejecting a treatment liquid to the collection chamber can be performed by adjusting the inflow and outflow of the outside air and the gas in the connection chamber.

Abstract: A method for manufacturing at least one kind of eukaryotic cells or a biosynthetic substance derived from the eukaryotic cells by proliferating the cells, which includes preparing an artificially synthesized peptide for promoting proliferation of the at least one kind of eukaryotic cells, incubating the eukaryotic cells in a culture medium, and adding the synthesized peptide at least once to the culture medium during the incubation process. The synthesized peptide includes an amino acid sequence selected from SEQ ID NOS: 1 to 18, and an amino acid sequence selected from SEQ ID NOS: 19 to 97.

Abstract: A cell proliferation promoter includes, as an active ingredient, an artificially synthesized peptide that includes (A) an amino acid sequence constituting a membrane-permeable peptide and (B) an amino acid sequence selected from SEQ ID NOs: 19 to 103 or an amino acid sequence formed by substituting, deleting and/or adding one or several amino acid residues in the selected amino acid sequence.

Abstract: A cell proliferation promoter includes, as an active ingredient, an artificially synthesized peptide that includes (A) an amino acid sequence constituting a membrane-permeable peptide and (B) an amino acid sequence selected from SEQ ID NOs: 19 to 103 or an amino acid sequence formed by substituting, deleting and/or adding one or several amino acid residues in the selected amino acid sequence.

Abstract: A cell-sheet releasing agent of the present invention contains an aminated polyrotaxane. The polyrotaxane constituting the skeleton of the cell-releasing agent of the present invention has a structure in which cavities of a plurality of cyclic molecules are threaded onto a linear molecule and both terminals of the linear molecule have a bulky cap bonded thereto so that the cyclic molecules are not dethreaded from the linear molecule. Furthermore, the aminated polyrotaxane contained in the cell-releasing agent of the present invention is a compound in which at least some of hydroxy groups in the cyclodextrin structure contained in the polyrotaxane are each substituted with a substituent having an amino group. According to this cell-sheet releasing agent, cultured cells anchored to the surface of a container can be released without damaging the cells and without controlling the temperature.