Abstract: The present invention provides a compound represented by the following formula [1?] or a salt thereof: wherein ring A, R2, R3, R4 and X are as defined in the description, and an agent for the treatment or prophylaxis of a pathology involving glucocorticoid, or a 11?HSD1 inhibitor, containing the compound or a salt thereof.

Abstract: The present invention provides a novel ?-galactoside-?2,3-sialyltransferase and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase, as well as a method for producing the sialyltransferase using such a microorganism. The present invention further provides a vector carrying a nucleic acid encoding the sialyltransferase, and a host cell transformed with the vector, as well as a method for producing a recombinant ?-galactoside-?2,3-sialyltransferase. The present invention further provides a method for preparing a sialylsugar chain, which uses the sialyltransferase of the present invention.

Abstract: The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof and an anti-HCV agent and an HCV polymerase inhibitor containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

Abstract: A package for rod-like smoking articles includes a box having an inner frame, a lid for opening/closing the opening end of the box, and the contents contained in the box. The contents include wrapper that wraps a bundle of filter cigarettes therein. The wrapper has a separable area demarcated by a separating line. The separable area is bonded to the inner face of the lid at a glue-applied area. When the lid is first opened, the separable area is separated from the wrapper by the swing movement of the lid to form a separated piece. The separated piece is kept in the state bonded to the inside of the lid.

Abstract: A method of treating a tobacco extract solution includes bringing an extract solution, which is obtained by extracting a natural tobacco material with an aqueous extracting solvent, into contact with a polymer containing, in its side chain, a functional group which traps metal ions including at least magnesium, thereby obtaining an extract solution with an amount of at least magnesium reduced.

Abstract: A 3,4-dihydrobenzoxazine compound of the present invention is represented by the following formula [1] (wherein X is a nitrogen atom or CR3; R1 is a hydrogen atom or a halogen atom; R2 is a C1-6 alkoxy group which may be substituted with the same or different 1 to 5 substituents selected from a halogen atom and a hydroxyl group; and R3 is a halogen atom. However, R1 is a halogen atom when X is CR3). This compound is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, etc.

Abstract: To provide a compound having an excellent inhibitory effect on vanilloid receptor subtype 1 (VR1) activity which is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, acute pain, chronic pain, neuropathic pain, rheumatoid arthritis pain, neuralgia, etc. and a pharmaceutical composition containing the compound.

Abstract: Shredded tobacco of the invention is treated with metal iodate. A method of treating tobacco of the present invention includes adding metal iodate to shredded tobacco to decompose tobacco specific nitrosamines and polyphenols in the shredded tobacco, thereby reducing the TSNAs and polyphenols.

Abstract: An antibody against AILIM (alternatively called JTT-1 antigen, JTT-2 antigen, ICOS and 8F4) was found to have a significant therapeutic effect on arthrosis, for example, rheumatoid arthritis and osteoarthritis, graft versus host disease, graft immune rejection, inflammation (hepatitis and inflammatory bowel diseases), diseased condition accompanied by the excessive production of an antibody against a foreign antigen triggered by immunological sensitization by the antigen.

Abstract: A non-combustion flavor inhalation article includes a heating device including a heater to be heated to a temperature between 80 and 140° C., and a roll including a tobacco sheet to be disposed in contact with the heater.

Abstract: The present invention provides a novel ?-galactoside-?2,6-sialyltransferase having high productivity and/or high activity, and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase. The present invention further provides a vector carrying a nucleic acid encoding the sialyltransferase, and a host cell transformed with the vector, as well as a method for producing a recombinant ?-galactoside-?2,6-sialyltransferase.

Abstract: The present invention aims at provision of a method for inhibiting remnant lipoprotein production and a remnant lipoprotein production inhibitor, which includes administering a compound having a CETP inhibitory activity to an administration subject. The remnant lipoprotein production inhibitor of the present invention contains a compound having a CETP inhibitory activity as an active ingredient.

Abstract: An object of the present invention is to search and identify novel antifungal proteins capable of inhibiting the growth of plant pathogenic microorganisms including Magnaporthe grisea and Rhizoctonia solani causing two major rice diseases at relatively low concentrations, and further to clone a gene for said protein. The present invention provides an antifungal protein which can be obtained from fraction(s) precipitated by ammonium sulfate precipitation using an aqueous extract from Pleurotus cornucopiae, wherein said protein has an antifungal activity against at least rice blast, and exhibits existence of a component having a molecular weight of about 15 kDa as determined by SDS-PAGE method; a gene encoding said protein and uses thereof.

Abstract: Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that the human monoclonal antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.

Abstract: The necessary number of delivery routes is accurately calculated corresponding to properties of an area. A system 100 for calculating the number of delivery routes calculates the necessary number of delivery routes when creating a plurality of delivery routes on which a staff delivers articles sequentially from a base to respective circular-visiting points in an area including the base and the circular-visiting points and returns to the base. A first average value calculating unit 310 calculates average value D of round-trip travel time between the base and the respective circular-visiting points, considering only circular-visiting points where round-trip travel time between the base and respective circular-visiting point amount to a predetermined rate or less when respective round-trip travel time are selected in order of increasing time, with the exception of the other circular-visiting points.

Abstract: An object of the present invention to provide a hybrid plant having a high fertility and a method for producing such a hybrid plant. The hybrid plant of the present invention is characterized by having two or more copies of a fertility restorer gene at two or more gene loci which do not have a complete linkage relationship. Further, the method of the present invention comprises introducing a fertility restorer gene by genetic engineering and placing two or more copies of a fertility restorer gene at two or more gene loci which do not have a complete linkage relationship.

Abstract: The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

Abstract: A method for gene introduction by which higher efficiency for gene introduction than that by the conventional Agrobacterium method may be attained simply and without injuring the tissue is disclosed. According to the method of the present invention, the efficiency of gene introduction into plant cells by a bacterium belonging to genus Agrobacterium is promoted by accompanying centrifugation of the plant cells or plant tissue.

Abstract: A compound of the following general formula [I]: wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.

Abstract: In a cigarette display system 1000, a plurality of wall units 500 can be linked in an vertical direction, and tray units 200 can be arranged in desired positions on a front surface of the wall units 500. Each of the tray units 200 can hold a plurality of magazine units 100 arranged in a lateral direction, and each of the magazine units 100 can hold a plurality of cigarette packs T arranged in a direction from front to back. Accordingly, it is possible to freely change a layout in which the cigarette packs T are arranged and displayed in the vertical and lateral directions so that cigarette cartons K or the like having a shape which cannot be accommodated in the magazine unit 100 can be displayed as well. As described above, the present invention provides the cigarette display system 1000 having a structure in which the layout of the cigarette packs T to be displayed or the like can be changed in various forms.