Abstract: Projectile systems are provided herein employing an inhibiting and/or marking substance for impairing/marking a living target, such as a human or animal target. The projectile systems provide effectiveness by impacting the target with sufficient force to cause the target to move into a simultaneously radially dispersing inhibiting/marking substance contained within a capsule of the projectile system. In preferred embodiments, the projectile system includes a generally spherical frangible projectile that is optimally filled to greater than about 50%, more preferably about 75% to 99% of its total volume, most preferably to about 90% of capacity, with the substance to be delivered to the target. One or more frangible projectiles are configured to fit with a shell casing configured to fit within a delivery device.