Abstract: The present disclosure relates to methods of treating a patient that has a low coronary ostia height. The methods can involve advancing a heart valve prosthesis to a native valve structure having an ostium and positioning the prosthesis to align a gap between major peaks of the prosthesis with the ostium to avoid obstruction of the ostium. The presently disclosed methods and prostheses can be effective at treating patients with a coronary ostia height of as low as 10 mm, 8 mm, 6 mm, or less.

Abstract: A valve prosthesis can be manufactured by aligning a membrane along a support frame and attaching the membrane to the support frame. The membrane can have a plurality of first fibers arranged in a warp direction and a plurality of second fibers arranged in a weft direction that is transverse relative to the warp direction. The plurality of first fibers and the plurality of second fibers can be woven together. The warp and weft directions can be oriented oblique relative to a longitudinal axis of the support frame.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a support frame, a valve anchor comprising an anchoring leg and a plurality of U-shaped members, and a connection member coupled to the support frame and slidably coupled to the anchoring leg.

Abstract: A heart valve prosthesis delivery device can be modified in situ to facilitate retrieval of the device from a patient after delivery of a heart valve prosthesis. The device can include a nose cone that permits enclosures of the device to be drawn together in an aligned configuration, reducing the likelihood that the device will get caught on the prosthesis or vasculature as the device is retrieved from the patient.

Abstract: Methods for delivering a pulmonary or mitral valve prosthesis using a transcatheter approach are provided. The implantation devices can utilize movable claspers for both positioning and anchoring the valve prostheses within the native cardiac valve, minimizing the extent of imaging necessary.

Abstract: Devices and methods for providing protection from embolisms and microembolisms in a subject undergoing catheter-based intravascular procedures. The embolic protection devices have an expandable support frame comprising U-shaped members and leg members which facilitate proper placements in a defective valve annulus. The filtering devices expand in the vessels and allow blood flow to continue through the vessels, thereby catching and removing debris of the flowing blood. Also disclosed are embolic protection devices for use with a sutureless valve prosthesis which is implanted via catheter-based methods.

Abstract: A valve prosthesis, implantation device, and methods for use are provided. The devices described herein may be used for transcatheter delivery of an aortic valve prosthesis or transapical delivery of a mitral valve prosthesis. The implantation device can utilize movable claspers for both positioning and anchoring the valve prosthesis, reducing the extent of imaging needed during the implantation procedure.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The valve prosthesis can include a valve anchor having a longitudinal axis and proximal and distal end portions. The valve anchor can include a plurality of U-shaped members and a plurality of anchoring legs, each of the plurality of anchoring legs comprising a connection aperture at a distal end portion thereof and a longitudinal slot extending along a length of the anchoring leg, wherein the plurality of anchoring legs and the plurality of U-shaped members can radially expand in stages to permit a native valve structure to be interposed therebetween for anchoring the valve prosthesis relative to the native valve structure.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: Methods of assembling and delivering a valve prosthesis and delivery system are disclosed herein. A method can include housing a valve prosthesis in a compacted state within a sheath of a delivery system. The valve prosthesis can include a valve anchor and a support frame coupled to the valve anchor, and the valve anchor can include a plurality of anchoring legs having a plurality of connection apertures. The method can further include slidably coupling a pin assembly around a core member so that the pin assembly is slidable longitudinally along the core member, and inserting a plurality of pins of the pin assembly through the plurality of connection apertures of the valve anchor and a plurality of lock apertures of the delivery system to engage the plurality of anchoring legs of the valve anchor.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a support frame, a valve anchor comprising an anchoring leg and a plurality of U-shaped members, and a suture coupled to the support frame and slidably coupled to the anchoring leg.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: A valve prosthesis, an implantation device, and methods for use are provided. The devices described herein may be used for transcatheter delivery of an aortic valve prosthesis or transapical delivery of a mitral valve prosthesis. The implantation device can utilize movable claspers for both positioning and anchoring the valve prosthesis, reducing the extent of imaging needed during the implantation procedure.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a core member and an engagement mechanism for releasably engaging a radially expandable valve anchor of the valve prosthesis along the core member. The engagement mechanism can include a pin assembly slidably coupled to the core member and a nose cone including a lock component slidably coupled along the core member to permit the valve anchor to disengage from the pin assembly.

Abstract: A crimper device can facilitate sheathing of a stent frame for vascular delivery. The device can include first and second components that rotate relative to each other to drive radial movement of one or more compression members of the device. The one or more compression members can direct and balance a compressive force within an aperture of the device. In use, the stent frame can be positioned within the aperture and be compacted by actuation of the compression members.