Abstract: A drug complex for delivery of a drug or other agent to a target cell, comprising a targeting carrier molecule which is selectively distributed to a specific cell type or tissue containing the specific cell type; a linker which is acted upon by a molecule which is present at an effective concentration in the environs of the specific cell type; and a drug or an agent to be delivered to the specific cell type. In particular, a drug complex for delivering a cytotoxic drug to prostate cancer cells, comprising a targeting carrier molecule which is selectively delivered to prostate tissue, bone or both; a peptide which is a substrate for prostate specific antigen; and a cytotoxic drug which is toxic to androgen independent prostate cancer cells.

Abstract: A drug complex for delivery of a drug or other agent to a target cell, comprising a targeting carrier molecule which is selectively distributed to a specific cell type or tissue containing the specific cell type; a linker which is acted upon by a molecule which is present at an effective concentration in the environs of the specific cell type; and a drug or an agent to be delivered to the specific cell type. In particular, a drug complex for delivering a cytotoxic drug to prostate cancer cells, comprising a targeting carrier molecule which is selectively delivered to prostate tissue, bone or both; a peptide which is a substrate for prostate specific antigen; and a cytotoxic drug which is toxic to androgen independent prostate cancer cells.

Abstract: A computer system to project and localize radiation treatment portals, i.e., field center, field borders, on patient skin without using a light field is disclosed. The system includes a multimedia software program that interacts with a three-dimensional digitizer which acquires the coordinates of any point in space that is accessible by the digitizer probe. The system constructs and employs coordinate system transformations from digitizer coordinates to room coordinates to radiation beam coordinates. For any point digitized, the invention system calculates the position of this point relative to the radiation field, and displays or signals to the user whether the digitized point is in the radiation field, outside of the field or on the field border. This is accomplished through a screen display of the radiation beam's eye view, an audio signal and/or LED light indicators mounted on the digitizer probe.