Abstract: An drive device (10) of a bicycle wheel comprises a first sub-assembly (23) with a freewheel (14) secured to one of the frame mounting brackets (20), and a second sub-assembly (52) supporting the hub (12), which is supported by the other mounting bracket (18) by means of a tube (76). A first transmission sleeve (44) secured to the freewheel is designed to cooperate by insertable engagement with a second transmission member (72) fixed to the hub (12) to couple or uncouple the mechanical link between the freewheel (14) and the hub (12) when the second sub-assembly (52) is respectively fitted or removed. The wheel can thus be replaced leaving the drive freewheel (14), transmission chain and derailleur in place.