Patents Assigned to JECHO BIOPHARMACEUTICALS CO LTD.
  • Bivalent bispecific antibody hybrid protein expression and preparation methods
    Patent number: 11535674
    Abstract: The present disclosure discloses a method for expressing and preparing a bivalent bispecific antibody. In the present disclosure, each portion of a bivalent bispecific antibody and an immune hybrid protein thereof is respectively expressed in a suitable prokaryotic or eukaryotic cell system, separated and purified by high-performance affinity chromatography, and then spliced in vitro by trans-splicing reaction mediated by an intein, to prepare the bivalent specific antibody and an immune hybrid protein thereof.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: December 27, 2022
    Assignees: SHANGHAI JIAO TONG UNIVERSITY, JECHO LABORATORIES INC., JECHO BIOPHARMACEUTICALS CO LTD.
    Inventors: Lei Han, Jianwei Zhu, Junsheng Chen, Kai Ding, Yueqing Xie, Hua Jiang, Huili Lu, Baohong Zhang, Lei Zhang