Abstract: Heparin-like compounds inhibit collagen-induced platelet aggregation in flowing whole blood. The compounds share properties displayed by native mast-cell derived heparin proteoglycans (HEP-PG) and/or heparin glycosaminoglycan (HEP-GAG) molecules. The compounds are useful in prevention and treatment of severe vascular disorders including arterial thrombosis.
Type:
Grant
Filed:
February 13, 2009
Date of Patent:
April 9, 2013
Assignee:
Jenny Ja Antti Wihurin Rahasto
Inventors:
Riitta Lassila, Petri Kovanen, Ken Lindstedt
Abstract: Heparin-like compounds inhibit collagen-induced platelet aggregation in flowing whole blood. The compounds share properties displayed by native mast-cell derived heparin proteoglycans (HEP-PG) and/or heparin glycosaminoglycan (HEP-GAG) molecules. The compounds are useful in prevention and treatment of severe vascular disorders including arterial thrombosis.
Type:
Application
Filed:
February 13, 2009
Publication date:
August 13, 2009
Applicant:
JENNY JA ANTTI WIHURIN RAHASTO
Inventors:
Riitta Lassila, Petri Kovanen, Ken Lindstedt
Abstract: The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic treatment of arterial thrombosis associated with vascular or microvascular injury and interventions. Said properties are related to a high coupling density of negatively charged heparin or heparin-like glycosaminoglycan molecules, present in multiple heparin or heparin-like glycosaminoglycans as well as in proteoglycans containing said multiple heparin or heparin-like glycosaminoglycans or lower-molecular-weight heparin or heparin-like glycosaminoglycans connected directly or through spacer/linker molecules to globular core molecules. Heparin-like compounds, with said properties are obtainable from mammalian mast cells, by tissue extraction or cell cultivation.
Type:
Grant
Filed:
July 17, 2007
Date of Patent:
March 17, 2009
Assignee:
Jenny Ja Antti Wihurin Rahasto
Inventors:
Riitta Lassila, Petri Kovanen, Ken Lindstedt
Abstract: The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic treatment of arterial thrombosis associated with vascular or microvascular injury and interventions. Said properties are related to a high coupling density of negatively charged heparin or heparin-like glycosaminoglycan molecules, present in multiple heparin or heparin-like glycosaminoglycans as well as in proteoglycans containing said multiple heparin or heparin-like glycosaminoglycans or lower-molecular-weight heparin or heparin-like glycosaminoglycans connected directly or through spacer/linker molecules to globular core molecules. Heparin-like compounds, with said properties are obtainable from mammalian mast cells, by tissue extraction or cell cultivation.
Type:
Application
Filed:
July 17, 2007
Publication date:
January 17, 2008
Applicant:
JENNY JA ANTTI WIHURIN RAHASTO
Inventors:
Riitta Lassila, Petri Kovanen, Ken Lindstedt
Abstract: The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic treatment of arterial thrombosis associated with vascular or microvascular injury and interventions. Said properties are related to a high coupling density of negatively charged heparin or heparin-like glycosaminoglycan molecules, present in multiple heparin or heparin-like glycosaminoglycans as well as in proteoglycans containing said multiple heparin or heparin-like glycosaminoglycans or lower-molecular-weight heparin or heparin-like glycosaminoglycans connected directly or through spacer/linker molecules to globular core molecules. Heparin-like compounds, with said properties are obtainable from mammalian mast cells, by tissue extraction or cell cultivation.
Type:
Application
Filed:
April 18, 2003
Publication date:
November 13, 2003
Applicant:
JENNY JA ANTTI WIHURIN RAHASTO
Inventors:
Riitta Lassila, Petri Kovanen, Ken Lindstedt