Abstract: The present invention relates to an isolated strain of lactic acid bacteria (LAB) for inhibiting drug-resistant Enterobacteriaceae, in which the isolated strain of the LAB includes Lacticaseibacillus rhamnosus JJ101, Lacticaseibacillus paracasei JJ102 and/or Lactiplantibacillus plantarum JJ103, and the isolated strain of the LAB inhibit growth of the drug-resistant Enterobacteriaceae. After orally administered to a subject, the isolated strain of the LAB can inhibit the growth of the drug-resistant Enterobacteriaceae, and thus can potentially be used to prevent, improve and/or treat the infection of the drug-resistant Enterobacteriaceae.