Patents Assigned to Jiangsu Hansoh Pharmaceutical Co., Ltd.
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Patent number: 9908908Abstract: The invention relates to a tenofovir prodrug and pharmaceutical uses thereof. In particular, the invention relates to a compound as shown in general formula (I): and its isomer, pharmaceutically acceptable salt, hydrate or solvate, as well as their uses in preparing drugs for treating viral infectious diseases, especially HIV infection, hepatitis B, or diseases caused by hepatitis B virus, wherein the definition of each substituent in the general formula (I) is as defined in the specification.Type: GrantFiled: July 10, 2013Date of Patent: March 6, 2018Assignee: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Fuyao Zhang, Dong Wei
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Patent number: 9566277Abstract: A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof are described.Type: GrantFiled: February 5, 2016Date of Patent: February 14, 2017Assignee: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Peng Cho Tang, Xin Li, Xiangqin Li, Yang Chen, Bin Wang, Zhe Zhu
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Patent number: 9512121Abstract: Provided are [1,2,4]triazol[4,3-a]pyridine derivatives as shown in the general formula (I), a preparation method therefor, and a pharmaceutical composition containing the derivative, wherein the pharmaceutical composition is used as a therapeutic agent, and especially used as a c-Met inhibitor and an immunosuppressant. Each substituent in the general formula (I) is the same as that defined in the specification.Type: GrantFiled: March 4, 2014Date of Patent: December 6, 2016Assignee: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Zhiming Zhao, Haiyang Wang, Chenchen Wu, Qingqing Qi
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Publication number: 20160222047Abstract: C-aryl glucoside derivatives, preparation methods thereof, and medical applications thereof are described. Specifically, compounds represented by formula I, and, tautomers, enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts of the compounds, preparation methods thereof, pharmaceutical compositions containing the compounds, and applications thereof are described. Compounds of formula (I) are useful as therapeutic agents, and particularly as sodium-dependent glucose contransporter protein (SGLT) inhibitors.Type: ApplicationFiled: August 19, 2014Publication date: August 4, 2016Applicant: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Huijuan ZHONG, Jianchun LIAO, Hongping YU, Yaochang XU, Qing LI, Jianghua CHEN, Peng GAO, Songliang TAN, Shaobao WANG
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Patent number: 9388133Abstract: The present invention relates to a pyrrole sulfonamide derivative, a preparation method for the same, and medical applications thereof. Specifically, the present invention relates to a novel pyrrole sulfonamide derivative as represented by formula (I), a preparation method for the derivative, a pharmaceutical composition comprising the derivative, and uses of the same as therapeutic agents, and particularly as gastric acid secretion inhibitors and potassium-competitive acid blockers (P-CABs), wherein each substituent of formula (I) is as defined in the description.Type: GrantFiled: November 6, 2013Date of Patent: July 12, 2016Assignee: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Jiong Lan, Piaoyang Sun, Lei Chen, Wei Peng, Xing Liu, Qing Dong
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Publication number: 20160122339Abstract: Provided are [1,2,4]triazol[4,3-a]pyridine derivatives as shown in the general formula (I), a preparation method therefor, and a pharmaceutical composition containing the derivative, wherein the pharmaceutical composition is used as a therapeutic agent, and especially used as a c-Met inhibitor and an immunosuppressant. Each substituent in the general formula (I) is the same as that defined in the specification.Type: ApplicationFiled: March 4, 2014Publication date: May 5, 2016Applicant: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Zhiming ZHAO, Haiyang WANG, Chenchen WU, Qingqing QI
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Patent number: 9273052Abstract: A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof are described.Type: GrantFiled: July 26, 2011Date of Patent: March 1, 2016Assignee: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Peng Cho Tang, Xin Li, Xiangqin Li, Yang Chen, Bin Wang, Zhe Zhu
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Patent number: 9233954Abstract: Disclosed are organic amine salts of azilsartan, a preparation method and use thereof. In particular, disclosed are organic amine salts of azilsartan, their preparation method, the pharmaceutical composition comprising the compound in a therapeutically effective quantity, and their use for the manufacture of antihypertensive medicaments.Type: GrantFiled: January 11, 2012Date of Patent: January 12, 2016Assignees: Jiangsu Hansoh Pharmaceutical Co., Ltd., Jiangsu Hansoh Pharmaceutical Group Co., Ltd., Jiangsu Hansoh Medicine Institute Co., Ltd.Inventors: Bigao Pan, Longbin Huang, Baohai Yang
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Patent number: 8951993Abstract: The present invention relates to compounds represented by formula (I), which can modulate the activity of protein kinases. The invention also relates to a composition containing a compound of formula (I), and a method for synthesizing and using such compound for preventing or treating ALK or cMet mediated disorders or conditions.Type: GrantFiled: February 22, 2012Date of Patent: February 10, 2015Assignee: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Baihua Hu, Kan He, Minsheng Zhang
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Patent number: 8642545Abstract: What is provided is EPO mimetic peptide derivatives defined as formula (I) and their pharmaceutical salts, the preparation thereof, wherein R1, R2, R3, R4, R5, n1, n2 are defined as described in description. A composition comprising of an EPO mimetic peptide derivative defined as formula (I) and its pharmaceutical salt. The uses of the derivatives and their pharmaceutical salts, as well as the uses of the compositions described above in treatment of diseases characterized by a deficiency of EPO or a low or defective red blood cell population.Type: GrantFiled: November 24, 2008Date of Patent: February 4, 2014Assignee: Jiangsu Hansoh Pharmaceutical Co., LtdInventors: Aifeng Lü, Changan Sun, Tao Jiang, Wentao Wu, Yali Wang
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Patent number: 8614182Abstract: This invention discloses GLP-1 analogues and their pharmaceutical salts, wherein the GLP-1 analogue comprises an amino acid sequence of general formula (I), wherein Lys represents a modified lysine with a lipophilic acid. The GLP-1 analogues provided by this invention have the function of human GLP-1, and a longer half-life in vivo compared with the human GLP-1. Uses of such compounds and compositions include treating non-insulin-dependent diabetes, insulin-dependent diabetes, and obesity.Type: GrantFiled: January 31, 2012Date of Patent: December 24, 2013Assignee: Jiangsu Hansoh Pharmaceuticals Co., Ltd.Inventors: Yali Wang, Aifeng Lü, Changan Sun, Hengli Yuan
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Publication number: 20130303518Abstract: The invention provides a method of inhibiting the catalytic activity of a protein kinase comprising contacting said protein kinase with a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the same, and also provides a method of treating a protein kinase related disorder comprising a step of administering to a patient in need thereof a therapeutically effective amount of the compound of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the same, wherein each substituent in formula (I) is same as defined in the description.Type: ApplicationFiled: September 27, 2012Publication date: November 14, 2013Applicants: Shanghai Hengrui Pharmaceutical Co., Ltd., Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Peng Cho Tang, Yidong Su, Yali Li, Lei Zhang, Fuqiang Zhao, Jialiang Yang, Ying Zhou, Pingyan Bie, Guangtao Qian, Minggang Ju
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Publication number: 20130296334Abstract: Disclosed are organic amine salts of azilsartan, a preparation method and use thereof. In particular, disclosed are organic amine salts of azilsartan, their preparation method, the pharmaceutical composition comprising the compound in a therapeutically effective quantity, and their use for the manufacture of antihypertensive medicaments.Type: ApplicationFiled: January 11, 2012Publication date: November 7, 2013Applicants: JIANGSU HANSOH PHARMACEUTICAL CO., LTD., JIANGSU HANSOH MEDICINE INSTITUTE CO., LTD., JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTDInventors: Bigao Pan, Longbin Huang, Baohai Yang
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Publication number: 20130131068Abstract: A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof are described.Type: ApplicationFiled: July 26, 2011Publication date: May 23, 2013Applicant: JIANGSU HANSOH PHARMACEUTICAL CO., LTD.Inventors: Peng Cho Tang, Xin Li, Xiangqin Li, Yang Chen, Bin Wang, Zhe Zhu
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Patent number: 8415349Abstract: The invention provides derivatives of azabicyclo alkane having formula (ID), and the method for making them, wherein each substitute in formula (ID) is same as defined in the description.Type: GrantFiled: September 14, 2012Date of Patent: April 9, 2013Assignee: Jiangsu Hansoh Pharmaceuticals Co., Ltd.Inventors: Peng Cho Tang, Zhigang Lin, Hejun Lü, Fuqiang Zhao, Li Li, Fanglong Yang, Jianghong Fu, Lin Wang, Guangyuan Shen, Dongliang Guan
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Publication number: 20130012705Abstract: Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Peng Cho Tang, Zhigang Lin, Hejun Lü, Fuqiang Zhao, Li Li, Fanglong Yang, Jianghong Fu, Lin Wang, Guangyuan Shen, Dongliang Guan
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Patent number: 8304411Abstract: Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.Type: GrantFiled: May 20, 2008Date of Patent: November 6, 2012Assignees: Jiangsu Hansoh Pharmaceutical Co., Ltd., Shanghai Hengrui Pharmaceutical Co. Ltd.Inventors: Peng Cho Tang, Zhigang Lin, Hejun Lu, Fuqiang Zhao, Li Li, Fanglong Yang, Jianghong Fu, Lin Wang, Guangyuan Shen, Dongliang Guan
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Patent number: 8178575Abstract: Derivatives of azabicyclo octane presented by formula (I), the method of making them, and the compositions containing the same and the uses thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV), wherein the substitutes in formula (I) have the same meanings as what is mentioned in the descriptions.Type: GrantFiled: October 30, 2007Date of Patent: May 15, 2012Assignees: Shanghai Hengrui Pharmaceutical Co., Ltd., Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Pengcho Tang, Zhigang Lin, Hejun Lü, Fuqiang Zhao, Li Li
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Publication number: 20100323949Abstract: What is provided is EPO mimetic peptide derivatives defined as formula (I) and their pharmaceutical salts, the preparation thereof, wherein R1, R2, R3, R4, R5, n1, n2 are defined as described in description. A composition comprising of an EPO mimetic peptide derivative defined as formula (I) and its pharmaceutical salt. The uses of the derivatives and their pharmaceutical salts, as well as the uses of the compositions described above in treatment of diseases characterized by a deficiency of EPO or a low or defective red blood cell population.Type: ApplicationFiled: November 24, 2008Publication date: December 23, 2010Applicant: Jiangsu Hansoh Pharmaceutical Co., Ltd.Inventors: Aifeng Lü, Changan Sun, Tao Jiang, Wentao Wu, Yali Wang