Abstract: An auto-disable safety syringe including a needle, a needle seat, a plunger, and a barrel. A cover of a needle seat chamber formed in the needle seat is provided with a splined hole having teeth and grooves. The needle seat has a ring block and an outer wall with splined teeth capable of passing through the grooves. A locking groove is formed in an inner cavity of the ring block and a locking head is formed on a connecting head to form a locking mechanism. Spiral grooves on the inner cavity engage with protrusions on the connecting head. When the locking head and the locking groove are interlocked and the plunger is retracted, the needle seat and the needle are retracted inside the barrel together. The syringe protects both patient and medical staff, is simple in structure, convenient to use and destructible.