Abstract: Disclosed is a method for preparing L-?-Glycerylphosphorylcholine with high yields and purity. The method uses phospholipase A1-based enzymatic hydrolysis, ion-exchange resin purification and silica gel column chromatography to prepare L-?-glycerylphosphorylcholin with purity up to 99.8% and a final yield up to 78.4%. The method disclosed is simple, cost-effective, environmentally friendly, and adaptable to industrial applications.
Type:
Grant
Filed:
March 24, 2011
Date of Patent:
February 25, 2014
Assignee:
Jiannan University
Inventors:
Yuanfa Liu, Kangyi Zhang, Xingguo Wang, Xiangyun Qian, Li Zhou, Zhihua Song