Patents Assigned to Jikai Biosciences, Inc.
  • Isothiazole derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
    Patent number: 9458151
    Abstract: PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, multi drug resistance, and inflammatory bowel disease. Also provided are methods for preparing and using the compounds represented by Formula I.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: October 4, 2016
    Assignee: Jikai Biosciences, Inc.
    Inventor: Yu Ge
  • Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
    Patent number: 9452995
    Abstract: PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, multi drug resistance, and inflammatory bowel disease. Also provided are methods for preparing and using the compounds represented by Formula I.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: September 27, 2016
    Assignee: Jikai Biosciences, Inc.
    Inventor: Yu Ge
  • Pyrimidine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
    Patent number: 9453003
    Abstract: PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, multi drug resistance, and inflammatory bowel disease. Also provided are methods for preparing and using the compounds represented by Formula I.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: September 27, 2016
    Assignee: Jikai Biosciences, Inc.
    Inventor: Yu Ge
  • PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
    Patent number: 9090594
    Abstract: PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts of the compounds as represented by Formula I. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, autoimmune diseases, allergic reactions, or organ transplant rejection. Also provided are methods for preparing the compounds represented by Formula I.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: July 28, 2015
    Assignee: JIKAI BIOSCIENCES, INC.
    Inventor: Yu Ge
  • PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
    Patent number: 8969584
    Abstract: A Pim kinase inhibitor compound having the structure represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit Pim kinase activity and can be used to prepare drugs for treating Pim kinase mediated diseases, such as cancers, autoimmune diseases, allergic reactions, or organ transplant rejection. Also provided are methods for preparing the compounds represented by Formula I.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 3, 2015
    Assignee: Jikai Biosciences, Inc.
    Inventor: Yu Ge
  • PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF
    Publication number: 20140162998
    Abstract: A Pim kinase inhibitor compound having the structure represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit Pim kinase activity and can be used to prepare drugs for treating Pim kinase mediated diseases, such as cancers, autoimmune diseases, allergic reactions, or organ transplant rejection. Also provided are methods for preparing the compounds represented by Formula I.
    Type: Application
    Filed: February 10, 2014
    Publication date: June 12, 2014
    Applicant: Jikai Biosciences, Inc.
    Inventor: Yu GE
  • PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF
    Publication number: 20140162999
    Abstract: PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts of the compounds as represented by Formula I. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, autoimmune diseases, allergic reactions, or organ transplant rejection. Also provided are methods for preparing the compounds represented by Formula I.
    Type: Application
    Filed: February 10, 2014
    Publication date: June 12, 2014
    Applicant: Jikai Biosciences, Inc.
    Inventor: Yu GE