Patents Assigned to Jikei University
  • Publication number: 20250197808
    Abstract: An object of the present invention is to provide a cultured cell sheet that can solve problems accompanied by defects of mucosal tissue, such as inflammation in mucosal tissues covering bone tissues and granulation tissue formation. The present inventors have found that a cultured cell sheet obtained by culturing cells collected from a nasal mucosal tissue as a source under specific conditions, and reconstructing the cells into a sheet are engrafted onto mucosal tissue defective sites; promote the regeneration of mucosal tissues; efficiently reduce inflammation that occurs in a middle ear bone tissue; and prevent fibrosis and the like that are characteristic of bone tissue inflammation, thereby demonstrating that the cultured cell sheet can solve the problems. It is also found that the cultured cell sheet of the present invention is also useful for preventing inflammation of bone tissues in areas other than the middle ear.
    Type: Application
    Filed: December 15, 2022
    Publication date: June 19, 2025
    Applicant: The Jikei University
    Inventors: Hiromi KOJIMA, Kazuhisa YAMAMOTO, Tsunetaro MORINO, Yoshiyuki KASAI
  • Publication number: 20220378948
    Abstract: The present invention is intended to provide a peptide that selectively binds to a metal surface. Specifically, the present invention relates to a peptide consisting of an amino acid sequence as set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, or SEQ ID NO: 8, or a peptide substantially identical to the aforementioned peptide, and a method for detecting a metal surface of a medical device, using these peptides.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 1, 2022
    Applicant: The Jikei University
    Inventors: Yuji TERAMURA, Akifumi YOSHIHARA, Tomonobu KODAMA, Yuichi MURAYAMA
  • Publication number: 20210085807
    Abstract: The present invention is intended to provide a peptide that selectively binds to a metal surface. The present invention relates to a peptide consisting of an amino acid sequence as set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, or SEQ ID NO: 21, or a peptide substantially identical to the aforementioned peptide, and a method for detecting a metal surface of a medical device, using these peptides.
    Type: Application
    Filed: January 16, 2019
    Publication date: March 25, 2021
    Applicants: The University of Tokyo, The Jikei University School of Medicine
    Inventors: Yuji Teramura, Tomoyuki Azuma, Akifumi Yoshihara, Tomonobu Kodama, Yuichi Murayama
  • Patent number: 10368980
    Abstract: The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cells in the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80° C., wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: August 6, 2019
    Assignees: Tokyo Women's Medical University, The Jikei University, CellSeed Inc.
    Inventors: Takanori Hama, Hiromi Kojima, Hiroshi Moriyama, Masayuki Yamato, Teruo Okano
  • Publication number: 20160220356
    Abstract: The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cells in the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80° C., wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet.
    Type: Application
    Filed: April 14, 2016
    Publication date: August 4, 2016
    Applicants: Tokyo Women's Medical University, The Jikei University, CellSeed Inc.
    Inventors: Takanori Hama, Hiromi Kojima, Hiroshi Moriyama, Masayuki Yamato, Teruo Okano
  • Patent number: 8740797
    Abstract: An ultrasonic therapeutic apparatus according to the present invention being provided with: an ultrasonic probe (102) provided with a group of ultrasonic transducers for diagnosis use and a group of ultrasonic transducers for therapeutic use of which at least apart of ultrasonic beam irradiation surfaces are arranged so as to overlap each other, a tomographic image producing means (8) that produces a tomographic image containing a diseased portion of a subject from reflection echoes received by the group of ultrasonic transducers for diagnosis use, a display means (10) that displays the tomographic image containing the diseased portion of the subject produced by the tomographic image producing means (8), a setting means (103) that sets an irradiation path of the therapeutic ultrasonic waves on the tomographic image containing the diseased portion of the subject displayed by the display means (10) and a control means (104) that produces irradiation path information corresponding to the irradiation path of the
    Type: Grant
    Filed: June 22, 2006
    Date of Patent: June 3, 2014
    Assignee: The Jikei University
    Inventors: Makoto Ogihara, Jun Kubota, Akira Sasaki, Hiroshi Furuhata, Toshihiro Ishibashi
  • Publication number: 20140042068
    Abstract: Provided is a radioactive substance collecting system and a radioactive substance collecting method which are capable of collecting radioactive substances with high efficiency. The radioactive substance collecting system according to the present invention removes radioactive substances (radioactive cesium 21) contained in a liquid (radioactive substances-contaminated water 20) and includes, as means for removing radioactive substances from the liquid, a radioactive substance trapping composite 1 including at least a magnetic particle 10 and a radioactive substance trapping compound 11 that traps radioactive substances, and magnetic accumulation means 30 for accumulating the radioactive substance trapping composite 1.
    Type: Application
    Filed: March 13, 2012
    Publication date: February 13, 2014
    Applicant: The Jikei University
    Inventor: Yoshihisa Namiki
  • Publication number: 20130289723
    Abstract: The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cell sir the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80 ° C., wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet.
    Type: Application
    Filed: September 15, 2011
    Publication date: October 31, 2013
    Applicants: The Jikei University, Tokyo Women's Medical University
    Inventors: Takanori Hama, Hiromi Kojima, Hiroshi Moriyama, Masayuki Yamato, Teruo Okano
  • Patent number: 7662098
    Abstract: An ultrasound probe comprises therapeutic transducers which include a plurality of arrayed first transducer elements and emit therapeutic ultrasounds to a subject, and diagnostic transducers which include a plurality of arrayed second transducer elements and emit diagnostic ultrasounds to the subject and receive the diagnostic ultrasounds, wherein the therapeutic transducers are stacked over the diagnostic transducers.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: February 16, 2010
    Assignees: Hitachi Medical Corporation, Jikei University
    Inventors: Jun Kubota, Akira Sasaki, Hiroshi Furuhata, Kazunari Ishida, Shinichiro Umemura, Takashi Azuma, Katsunori Asafusa
  • Patent number: 7241616
    Abstract: Disclosed is a human cell/tissue culturing system including a plurality of incubators, each incubator capable of aseptically storing/culturing cell(s) or tissue(s) derived from a (human) individual and identifying the cell(s) or the tissue(s) during incubation, wherein each incubator comprises a detector corresponding to an individual key, the response of the detector permitting opening/closing of a door of each incubator, the response of the detector of one incubator triggering the interception of the function of the detector(s) of other incubator(s) to consequently inhibit opening/closing of the door(s) of the other incubator(s).
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: July 10, 2007
    Assignees: Jikei University School of Medicine, Hirasawa Works
    Inventors: Tsuneya Ohno, Kikuo Hirasawa, Masanobu Hattori
  • Patent number: 7198906
    Abstract: Disclosed herein is a method for determining the drug sensitivity of a microbe which comprises pouring a microbial suspension into each of the compartments or wells at a position which is in the vicinity of an electrode for measuring dissolved oxygen concentration, measuring current from each electrode at a second time interval for a third time period, each time is obtained based upon each of the measured currents at which the maximum current is obtained, obtaining each current value within a fourth time period which starts from the time at which the maximum current is obtained, detecting drug sensitivity based upon the variation condition of each current value during the fourth time period. The method allows rapid drug susceptibility measurements.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: April 3, 2007
    Assignees: Jikei University School of Medicine, Japan as Represented by Director-General of National Institute of Advanced Industrial Science and Technology, Ministry of Economy, Trade and Industry, Daikin Industries, Ltd.
    Inventors: Katsuhiko Machida, Sadayori Hoshina, Takashi Ushida, Junichiro Arai, Hideo Katayama, Chiaki Okumura, Yoshihisa Amano
  • Patent number: 7081353
    Abstract: A method and apparatus wherein measurement current values output from a first oxygen sensor and a second oxygen sensor are time sequentially measured. Each moving average value is calculated from each sequential measurement current value. Each time differential value is calculated from the pair of each calculated moving average values, by least squares approximation. Then, drug susceptibility is measured based upon each calculated time differential value, so that drug the susceptibility measurement is performed quickly or accurately.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: July 25, 2006
    Assignees: Jikei University School of Medicine, Japan as Represented by Director-General of National Institute of Advanced Industrial Science and Technology, Ministry of Economy, Trade and Industry, Daikin Industries, Ltd.
    Inventors: Katsuhiko Machida, Sadayori Hoshina, Takashi Ushida, Junichiro Arai, Hideo Katayama, Chiaki Okumura, Yoshihisa Amano
  • Patent number: 6846286
    Abstract: An endoscope system is provided, including an endoscope having a flexible inserting tube to be inserted into a human body and a plurality of bending sensors distributed over the flexible inserting tube along the longitudinal direction thereof. Each of the bending sensors detects the local bending state of the flexible inserting tube at the location the bending sensor are provided. A computer adapted to receive data on the local bending state from each of the plurality of bending sensors is also provided. The computer generates a graphical image representing the geometrical configuration of the flexible inserting tube from the data on the local bending states. A monitor connected to the computer to display the graphical image generated by the computer.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: January 25, 2005
    Assignees: PENTAX Corporation, The Jikei University School of Medicine
    Inventors: Naoki Suzuki, Kazuki Sumiyama, Naoshi Koizumi, Akira Sugiyama, Tetsuya Tarumoto, Toshiyuki Hashiyama, Motoko Kawamura, Takayuki Enomoto, Minoru Matsushita, Tetsuya Nakamura, Kenichi Ohara, Satoshi Takami
  • Patent number: 5824839
    Abstract: Disclosed are methods that achieve i) site-directed delivery, ii) in situ amplification, and iii) sustained expression of an exogenous gene product within renal glomeruli. An exogenous gene, E. coli .beta.-galactosidase, was introduced into cultured rat mesangial cells using a replication-defective retrovirus, and stable infectants were administered to a rat kidney via the renal artery. In the injected kidney, the engineered, cultured mesangial cells populated 40% of glomeruli site-specifically. The gene product was detected throughout a 14-week period of observation. In an alternative method, engineered, cultured mesangial cells were injected into a kidney subjected to an antibody that induces mesangiolysis followed by mesangial regeneration. Under these conditions, expression of .beta.-galactosidase was dramatically amplified in situ and high level expression continued for at least 8 weeks.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: October 20, 1998
    Assignee: The Jikei University School of Medicine
    Inventor: Masanori Kitamura
  • Patent number: 5667777
    Abstract: Disclosed are methods that achieve i) site-directed delivery, ii) in situ amplification, and iii) sustained expression of an exogenous gene product within renal glomeruli. An exogenous gene, E. coli .beta.-galactosidase, was introduced into cultured rat mesangial cells using a replication-defective retrovirus, and stable infectants were administered to a rat kidney via the renal artery. In the injected kidney, the engineered, cultured mesangial cells populated 40% of glomeruli site-specifically. The gene product was detected throughout a 14-week period of observation. In an alternative method, engineered, cultured mesangial cells were injected into a kidney subjected to an antibody that induces mesangiolysis followed by mesangial regeneration. Under these conditions, expression of .beta.-galactosidase was dramatically amplified in situ, and high level expression continued for at least 8 weeks.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 16, 1997
    Assignee: The Jikei University School of Medicine
    Inventor: Masanori Kitamura
  • Patent number: 5580558
    Abstract: Disclosed are methods that achieve i) site-directed delivery, ii) in situ amplification, and iii) sustained expression of an exogenous gene product within renal glomeruli. An exogenous gene, E. coli .beta.-galactosidase, was introduced into cultured rat mesangial cells using a replication-defective retrovirus, and stable infectants were administered to a rat kidney via the renal artery. In the injected kidney, the engineered, cultured mesangial cells populated 40% of glomeruli site-specifically. The gene product was detected throughout a 14-week period of observation. In an alternative method, engineered, cultured mesangial cells were injected into a kidney subjected to an antibody that induces mesangiolysis followed by mesangial regeneration. Under these conditions, expression of .beta.-galactosidase was dramatically amplified in situ, and high level expression continued for at least 8 weeks.
    Type: Grant
    Filed: November 17, 1993
    Date of Patent: December 3, 1996
    Assignee: The Jikei University School of Medicine
    Inventor: Masanori Kitamura