Abstract: A blood smear image staining normalization method, apparatus, device, and storage medium are provided. The method includes: extracting an illumination feature map and a first image based on a blood smear image and an illumination prior map; obtaining an enhanced image according to the first image and the illumination feature map; decomposing the enhanced image into a set of octave-spaced band-pass images and a low-resolution residual layer image; performing feature extraction on the low-resolution residual layer image to obtain a first feature map, extracting a first morphological representation and a staining contour based on the first feature map, and combining the first morphological representation with the staining contour to obtain a normalized low-resolution residual layer image; performing feature extraction on the band-pass images to obtain a second morphological representation, and combining the second morphological representation with the staining contour.

Abstract: Provided is a non-human mammalian model expressing IL-8 and use thereof. Specifically. provided is a non-human mammalian model expressing IL-8. The non-human mammalian model expressing IL-8 can be better used to prepare a tumor-bearing non-human mammalian model expressing IL-8 which can be used for studying the effect of IL-8 on tumors and screening or identifying potential therapeutic agents for the prevention and/or treatment of tumors.