Abstract: An inflation pump box with a detachable power supply comprising a box housing and a battery pack connected to a surface of the box housing, wherein the surface of the box housing is provided with a cavity which is internally provided with a connection block connected to the box housing, a snap-in plate is detachably connected above the connection block, the center of the snap-in plate is provided with a battery chamber for installing the battery pack, slideways for enabling the battery pack to slide are provided on two sides of the battery chamber, a lock bar for fixing the battery pack is provided in front of the battery chamber, a lock block is provided in the center of the battery chamber, and the lock block is internally connected to a contact sheet which is detachably fitted and connected to the battery pack. The box is convenient for the user.