Patents Assigned to JITSUBO Co., Ltd.
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Patent number: 11098078Abstract: The present invention has an object of providing a peptide synthesis method using a carrier capable of reversibly repeating the dissolved state and the insolubilized state, wherein the problem of an amino acid active species existing in the reaction system in de-protection reaction can be easily solved. The present invention provides a peptide synthesis method comprising the following steps: a step of condensing an N-Fmoc protected amino acid with a peptide having a C-terminal protected with a carrier which is crystallized according to a change of a composition of a dissolving solvent, in the presence of a condensing agent, to obtain an N-Fmoc-C-carrier protected peptide, a step of adding an alkylamine having 1 to 14 carbon atoms or hydroxyl amine to the reaction system, a step of de-protecting the N-terminal, and a step of changing the composition of the solvent dissolving the C-carrier protected peptide, to crystallize and separate the peptide.Type: GrantFiled: March 2, 2016Date of Patent: August 24, 2021Assignee: JITSUBO Co., Ltd.Inventors: Yusuke Kono, Hideaki Suzuki, Susumu Muto
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Publication number: 20210139532Abstract: The present invention has an object of shortening the process time and reducing use of a poor solvent for solidifying a carrier (Tag)-peptide component, by removing impurities without conducting solid-liquid separation (condensation, solid-liquid separation and drying operation) of a Tag-peptide component, in an Fmoc method using a Tag for liquid phase peptide synthesis.Type: ApplicationFiled: April 13, 2019Publication date: May 13, 2021Applicant: JITSUBO Co., Ltd.Inventors: Hideaki SUZUKI, Susumu MUTO, Shuji FUJITA, Daisuke KUBO
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Patent number: 10654891Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: GrantFiled: May 17, 2016Date of Patent: May 19, 2020Assignee: Jitsubo Co., Ltd.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
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Patent number: 10633418Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: GrantFiled: May 17, 2016Date of Patent: April 28, 2020Assignee: JITSUBO CO., LTD.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
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Patent number: 9376467Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: GrantFiled: February 28, 2012Date of Patent: June 28, 2016Assignee: JITSUBO CO., LTD.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
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Patent number: 9365615Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: GrantFiled: September 9, 2013Date of Patent: June 14, 2016Assignee: JITSUBO CO., LTD.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
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Patent number: 9284348Abstract: Disclosed are a carrier for use for separation purpose and a method for separation of a compound which enable a chemical reaction to be performed in a liquid phase, enable a compound of interest to be separated from the liquid phase after the completion of the reaction readily, enable the separated compound to be evaluated by structural analysis or the like while the compound being bound to the carrier, and enable the compound to be separated from the carrier readily. A carrier for separation which has a reaction site capable of reacting with other compound on a benzene ring, and a long-chain group having a specified carbon atom(s) at each of the ortho-position and the para-position of the reaction site through an oxygen atom.Type: GrantFiled: December 20, 2013Date of Patent: March 15, 2016Assignee: JITSUBO Co., Ltd.Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
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Publication number: 20150073121Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: ApplicationFiled: September 9, 2013Publication date: March 12, 2015Applicant: JITSUBO Co., Ltd.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
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Publication number: 20140107319Abstract: Disclosed are a carrier for use for separation purpose and a method for separation of a compound which enable a chemical reaction to be performed in a liquid phase, enable a compound of interest to be separated from the liquid phase after the completion of the reaction readily, enable the separated compound to be evaluated by structural analysis or the like while the compound being bound to the carrier, and enable the compound to be separated from the carrier readily. A carrier for separation which has a reaction site capable of reacting with other compound on a benzene ring, and a long-chain group having a specified carbon atom(s) at each of the ortho-position and the para-position of the reaction site through an oxygen atom.Type: ApplicationFiled: December 20, 2013Publication date: April 17, 2014Applicants: JITSUBO Co., Ltd., National University Corporation, Tokyo University of Agriculture and TechnologyInventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
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Patent number: 8633298Abstract: A carrier for use for separation purpose and a method for separation of a compound enable a chemical reaction to be performed in a liquid phase, a compound of interest to be separated from the liquid phase after the completion of the reaction readily, the separated compound to be evaluated by structural analysis or the like while the compound is being bound to the carrier, and the compound to be separated from the carrier readily. A carrier for separation is also provided which has a reaction site capable of reacting with other compound(s) on a benzene ring, and a long-chain group having a specified carbon atom(s) at each of the ortho-position and the para-position of the reaction site through an oxygen atom.Type: GrantFiled: September 20, 2006Date of Patent: January 21, 2014Assignee: Jitsubo Co., Ltd.Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
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Publication number: 20130345393Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: ApplicationFiled: February 28, 2012Publication date: December 26, 2013Applicant: JITSUBO Co., Ltd.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
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Patent number: 8293948Abstract: A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.Type: GrantFiled: January 9, 2012Date of Patent: October 23, 2012Assignee: Jitsubo Co., Ltd.Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
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Publication number: 20120108788Abstract: A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.Type: ApplicationFiled: January 9, 2012Publication date: May 3, 2012Applicant: JITSUBO Co., Ltd.Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
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Patent number: 8093435Abstract: A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.Type: GrantFiled: February 19, 2007Date of Patent: January 10, 2012Assignee: JITSUBO Co., Ltd.Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
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Publication number: 20090299103Abstract: A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.Type: ApplicationFiled: February 19, 2007Publication date: December 3, 2009Applicants: NATIONAL UNIVERSITY CORPORATION, TOKYO UNIVERSITY, JITSUBO CO., LTD.Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono