Abstract: A purified oligosaccharide compound having antithrombotic activity or a mixture of a homologous compound thereof and a pharmaceutically acceptable salt thereof, a preparation method for the mixture, a pharmaceutical composition containing the mixture, and uses thereof serving as an intrinsic factor X-enzyme (Xase) inhibitor in the preparation of drugs for preventing and/or treating thrombotic diseases.
Abstract: Disclosed are a Fuc3S4S substituted oligoglycosaminoglycan with a weight-average molecular weight (Mw) of about 4.5-9 kD, a pharmaceutical composition containing the Fuc3S4S substituted oligoglycosaminoglycan, a preparation method thereof and a use thereof in preparing medicines for preventing and/or treating thrombotic diseases.
Type:
Grant
Filed:
December 19, 2014
Date of Patent:
June 23, 2020
Assignee:
JIUZHITANG CO., LTD.
Inventors:
Jinhua Zhao, Jinxing He, Mingyi Wu, Zhiwen Liu, Na Gao, Longyan Zhao, Zi Li, Feng Lu, Li Xu, Chuang Xiao, Lian Yang, Jun Chen, Lutan Zhou, Wenlie Peng, Jikai Liu
Abstract: A low-molecular-weight fucosylated glycosaminoglycan (aTFG) containing 2,5-anhydrated talose, alditol, glycosylamine or N-substituted glycosylamine monosaccharide composition thereof, preparation method thereof, pharmaceutical compositions containing the aTFG, and use thereof for preventing and/or treating thrombotic diseases are provided. The aTFG has potent anticoagulant activity targeting at intrinsic coagulation factor Xase, and inhibiting thrombogenesis, and therefore can be used as drugs for preventing and/or treating cardiovascular and cerebrovascular diseases.
Type:
Grant
Filed:
December 20, 2013
Date of Patent:
December 3, 2019
Assignee:
Jiuzhitang Co., Ltd.
Inventors:
Jinhua Zhao, Mingyi Wu, Na Gao, Zi Li, Sensen Lai, Longyan Zhao
Abstract: Provided are a low-molecular-weight fucosylated glycosaminoglycan derivative (derivative of Low molecular weight Fucosylated Glycosaminoglycan, dLFG) having anticoagulant activity, a preparation method thereof, a pharmaceutical composition comprising dLFG or a pharmaceutically acceptable salt thereof, and the use of dLFG and pharmaceutical composition thereof in preparing medicine for treating thrombotic diseases.
Type:
Grant
Filed:
December 20, 2013
Date of Patent:
February 20, 2018
Assignee:
Jiuzhitang Co., Ltd.
Inventors:
Jinhua Zhao, Jikai Liu, Mingyi Wu, Na Gao, Feng Lu, Zi Li