Patents Assigned to Johann A. Wulfing
  • 7-(Oxoalkyl)-1,3-di-n-iso-propyl xanthines and their production
    Patent number: 4291037
    Abstract: 7-(Oxoalkyl)-1,3-dialkyl xanthines whose substituents in the 1- and 3-positions are alkyl groups of 2 to 6 carbons, cyclohexyl, alkoxyalkyl or hydroxyalkyl, such as 7-(3-oxobutyl)-1,3-di-n-butylxanthine, are effective vasodilators, having a marked activity in promoting blood flow through skeletal muscle, while at the same time exhibiting low toxicity.
    Type: Grant
    Filed: June 4, 1979
    Date of Patent: September 22, 1981
    Assignee: Johann A. Wulfing
    Inventors: Gunther Brenner, Joachim Goring, Eskendar Ali Khan, Oskar Rohte, Manfred Tauscher
  • Pharmaceutical compositions
    Patent number: 4256750
    Abstract: It has been found that 1,3-di-n-butyl-7-(2-oxopropyl)xanthine is a particularly effective agent for increasing oxygen partial pressure and contractility in ischaemic and skeletal muscle. Pharmaceutical compositions containing 1 to 30 mg of this agent are described.
    Type: Grant
    Filed: December 11, 1979
    Date of Patent: March 17, 1981
    Assignee: Johann A. Wulfing
    Inventors: Joachim E. Goring, Peter P. Ochlich
  • 7-(Oxoalkyl)-1,3-dialkyl xanthines, and medicaments containing them
    Patent number: 4242345
    Abstract: 7-(Oxoalkyl)-1,3-dialkyl xanthines whose substituents in the 1- and 3-positions are alkyl groups of 2 to 6 carbons, cyclohexyl, alkoxyalkyl or hydroxyalkyl, such as 7-(3-oxobutyl)-1,3-di-n-butylxanthine, are effective vasodilators, having a marked activity in promoting blood flow through skeletal muscle, while at the same time exhibiting low toxicity.
    Type: Grant
    Filed: September 19, 1978
    Date of Patent: December 30, 1980
    Assignee: Johann A. Wulfing
    Inventors: Gunther Brenner, Joachim Goring, Eskendar Ali Khan, Oskar Rohte, Manfred Tauscher
  • Pharmaceutical composition containing a xanthine derivative
    Patent number: 4225607
    Abstract: It has been found that 1,3-di-n-butyl-7-(2-oxopropyl)xanthine is a particularly effective agent for increasing oxygen partial pressure and contractility in ischaemic and skeletal muscle. Pharmaceutical compositions containing 1 to 30 mg of this agent are described.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: September 30, 1980
    Assignee: Johann A. Wulfing
    Inventors: Joachim E. Goring, Peter P. Ochlich
  • Theophylline salts of 5-methylisoxazole-3-carboxylic acid
    Patent number: 4092417
    Abstract: The salts of N-unsubstituted, N-monosubstituted and N,N-disubstituted 7-(3-amino-2-hydroxypropyl)theophylline and 5-methylisoxazole-3-carboxylic acid are hypolipidaemic agents. The compounds, of which the 7-[3-(N-methyl-N-2-hydroxyethyl)amino-2-hydroxypropyl]-theophylline salt of 5-methylisoxazole-3-carboxylic acid is a representative embodiment, are prepared by allowing the isoxazole acid and the amine to react.
    Type: Grant
    Filed: December 8, 1976
    Date of Patent: May 30, 1978
    Assignee: Johann A. Wulfing
    Inventors: Karl Credner, Joachim Goring, Gunter Brenner, Manfred Tauscher
  • Esters of the ophyllinylacetic acid
    Patent number: 4060617
    Abstract: A compound of the formula ##STR1## wherein R is hydrogen or methyl, n is a number from 1 to 4 and `Acyl` is nicotinoyl, 3-methylpyrazole-5-carboyl, 3-methyl-isoxazolyl-5-carboyl, 5-n-butylpyridin-2-carboyl, 2-(4-chlorophenoxy)-2-methyl-propionyl, 2-acetoxybenzoyl or theophyllinyl-7-acetyl, are useful for their effect on serum lipoids and, in particular, for treating adverse hyperlipidemic states in humans.
    Type: Grant
    Filed: April 1, 1976
    Date of Patent: November 29, 1977
    Assignee: Johann A. Wulfing
    Inventors: Karl Credner, Berthold Geisel, Gunter Brenner, Manfred Tauscher
  • Esters of 5-n-butylpyridine-2 carboxylic acid and pharmaceutical compositions containing these compounds
    Patent number: 3995046
    Abstract: Novel 3,4,5-trimethoxybenzoyloxyalkyl esters of 5-n-butylpyridine-2-carboxylic acid are superior to the free acid in their ability to reduce mammalian hypertension.
    Type: Grant
    Filed: September 11, 1975
    Date of Patent: November 30, 1976
    Assignee: Johann A. Wulfing
    Inventors: Karl Credner, Berthold Geisel, Oskar Rohte, Manfred Tauscher
  • 3-Methylpyrazole-5-carboxylates and medicaments containing these compounds
    Patent number: 3980646
    Abstract: This invention relates to 3-methylpyrazole-5-carboxylates, to processes for the preparation of said compounds and to pharmaceutical compositions containing said compounds.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: September 14, 1976
    Assignee: Johann A. Wulfing
    Inventors: Gunter Brenner, Karl Credner, Joachim Goring, Manfred Tauscher
  • Cardioglycoside derivatives of the strophanthidin type, a process for their manufacture and medicinal preparations containing these compounds
    Patent number: 3975373
    Abstract: Cyclic acetals or ketals of cardioglycosides derived from k-strophanthidin or strophanthidol are more readily absorbed by the stomach and intestine than the parent cardioglycoside. The acetals are produced by reaction of the parent cardioglycoside, e.g., strophanthidindigitoxide, with an aldehyde or ketone, or the corresponding acetal or ketal, in the presence of an acid condensation catalyst, to produce the k-strophanthidin derivative optionally followed by reduction to the strophanthidiol derivative.
    Type: Grant
    Filed: June 12, 1975
    Date of Patent: August 17, 1976
    Assignee: Johann A. Wulfing Fabrik Pharmazeutischer Praparate
    Inventor: Kurt H. Schmidt
  • Cardioglycoside derivatives of the strophanthidin type, a process for their manufacture and medicinal preparations containing these compounds
    Patent number: 3951946
    Abstract: Cyclic acetals or ketals of cardioglycosides derived from k-strophanthidin or strophanthidol are more readily absorbed by the stomach and intestine than the parent cardioglycoside. The acetals are produced by reaction of the parent cardioglycoside, e.g., strophanthidindigitoxide, with an aldehyde or ketone, or the corresponding acetal or ketal, in the presence of an acid condensation catalyst, to produce the k-strophanthidin derivative optionally followed by reduction to the strophanthidiol derivative.
    Type: Grant
    Filed: August 10, 1971
    Date of Patent: April 20, 1976
    Assignee: Johann A. Wulfing Fabrik Pharmazeutischer Praparate
    Inventor: Kurt H. Schmidt
  • 1,3-BIS(Beta-ethylhexyl)-5-amino-5-methylhexahydropyrimidine-pyridine- 3-carboxylate, process for its preparation and pharmaceutical compositions containing this compound
    Patent number: 3946013
    Abstract: 1,3-BIS(.beta.-ETHYLHEXYL)-5-AMINO-5-METHYLHEXAHYDROPYRIMIDINE PYRIDINE-3-CARBOXYLATE(HEXETIDINE NICOTINATE), WHICH HAS GREATER BACTERIOSTATIC ACTIVITY AND LOWER TOXICITY IN COMPARISON WITH HEXETIDINE OR OTHER SALTS OF HEXETIDINE, IS PREPARED BY REACTING HEXETIDINE OR AN ACID ADDITION SALT THEREOF WITH NICOTINIC ACID IN AN ORGANIC SOLVENT.
    Type: Grant
    Filed: February 28, 1974
    Date of Patent: March 23, 1976
    Assignee: Johann A. Wulfing
    Inventors: Manfred Tauscher, Joachim Goring, Wolfgang Busch, Oskar Rohte