Abstract: An auto-aspirating hypodermic syringe supporting and operating device for self-administered injection of hypodermic medication, insulin or the like comprising an elongated thin main plate member having longitudinal slots, a carriage assembly slidably mounted on the plate member for reciprocative longitudinal movement through projecting and retracting strokes including a spring biased syringe carrier member having front and rear holder portions to removably hold the barrel and a back member fixed to the carrier member to slide longitudinally with the carrier member. A pivoted latch trigger member is pivoted on the plate member to latch the carriage assembly in a cocked position and a stop supporting bracket extends from the plate member having movable stop members and a stop positioning cam plate to position the said stop members at an intercepting first position and retracted second position relative to an enlarged head of the plunger.