Patents Assigned to Johnson & Johnson AB
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Patent number: 9606112Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: GrantFiled: October 6, 2014Date of Patent: March 28, 2017Assignee: JOHNSON & JOHNSON ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 9285361Abstract: There is provided a method for the analysis of circulating antibodies comprising the steps: a) providing an analysis device comprising a substrate, and provided on said substrate at least one sample addition zone, at least one retaining zone, at least one sink, and at least one flow path connecting the sample addition zone, the retaining zone and the sink, wherein the flow path is open and comprises projections substantially vertical to the surface of said substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of said sample is achieved and such that cells can flow through the projections, wherein said retaining zone comprises at least one affinity binding means to which cell structures are bound, b) adding at least one sample to a sample addition zone, and c) reading a result, wherein circulating antibodies directed against cell structures are determined.Type: GrantFiled: July 2, 2009Date of Patent: March 15, 2016Assignee: JOHNSON & JOHNSON ABInventors: Ib Mendel-Hartvig, Christer Pettersson, Gerd Rundström
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Patent number: 9279768Abstract: A fluorescence reader for an optical assay arrangement that includes a polymeric sample substrate having a reaction site-surface and a substrate surface. The fluorescence reader includes a light source arranged to illuminate the reaction site-surface through the substrate surface, and a detector device arranged to detect fluorescent light emitted from the reaction site-surface and transmitted through the substrate surface, the substrate surface being configured to increase transmission of emitted fluorescent light by suppression of total internal reflection.Type: GrantFiled: March 31, 2014Date of Patent: March 8, 2016Assignee: JOHNSON & JOHNSON ABInventors: Tomas Lindstrom, Ib Mendel-Hartvig, Ove Öhman, Johan Backlund, Kennet Vilhelmsson
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Patent number: 9056318Abstract: A device and method for the separation of a component in a liquid sample prior to the detection of an analyte in said sample, wherein a sample is added to a receiving zone on a substrate, said substrate further optionally comprising a reaction zone, a transport or incubation zone connecting the receiving and reaction zone, respectively, forming a flow path on a substrate, wherein said substrate is a non-porous substrate, and at least part of said flow path consists of areas of projections substantially vertical to said surface, and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such, that lateral capillary flow of said liquid sample in said zone is achieved, and where means for separation are provided adjacent to the zone for receiving the sample. Said means for separation are chosen among filter means, optionally enhanced by affinity binding and/or aggregation; magnetic means, also optionally enhanced by affinity binding and/or aggregation; and acoustic means.Type: GrantFiled: March 23, 2005Date of Patent: June 16, 2015Assignee: JOHNSON & JOHNSON ABInventors: David Bergman, Ib Mendel-Hartvig, Simon Uhrberg
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Patent number: 8974749Abstract: There is disclosed an analysis device for the analysis of a liquid sample, said device comprising a substrate, said substrate at least partly having projections substantially vertical to the surface of said substrate, and having a height (H1), diameter (D1) and center-to-center distance (x1, y1) such, that lateral capillary flow of said liquid sample is achieved, wherein that said substrate comprises at least one substrate zone comprising projections substantially vertical to the surface of said substrate, and having a height (H2), diameter (D2) and center-to-center distance (x2, y2), such, that lateral capillary flow of said liquid sample is achieved and wherein at least one substance is applied at least partly between the projections in said at least one substrate zone. Moreover there is provided a method for the analysis of a sample. The device and method provide for instance improved control of the dissolution of a substance.Type: GrantFiled: June 12, 2009Date of Patent: March 10, 2015Assignee: Johnson & Johnson ABInventors: David Bergman, Ib Mendel-Hartvig, Annika Lindström
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Patent number: 8877142Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: GrantFiled: June 20, 2007Date of Patent: November 4, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 8821812Abstract: An absorbing zone for establishing and/or maintaining fluid transport through or along at least one fluid passage is manufactured on the basis of a non-porous substrate having a surface, the non-porous substrate having projections substantially perpendicular to the surface, and the projections having a height, diameter and a distance or distances between the projections such, that lateral capillary flow of the fluid in the zone is achieved.Type: GrantFiled: June 19, 2006Date of Patent: September 2, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 8822231Abstract: A method for the analysis of at least two analytes in a liquid sample, in which a substrate is provided wherein at least two different types of capturing molecules are immobilized on the substrate and wherein each type of capturing molecule has specific affinity for an analyte. The sample is contacted with capturing molecules, wherein for at least one analyte to be analyzed contact is induced between the capturing molecules and a labelled detection molecule with specific affinity for the analyte, and for at least one another analyte to be contact is induced between the capturing molecules and a labelled version of the analyte. A detectable signal is measured from the labelled detection molecule and the labelled analyte on the substrate, wherein the concentration of the labelled analyte is adapted to the concentration of the analyte in the sample.Type: GrantFiled: April 14, 2009Date of Patent: September 2, 2014Assignee: Johnson & Johnson ABInventors: Jonas Melin, Christina Jönsson
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Publication number: 20140212984Abstract: A fluorescence reader for an optical assay arrangement that includes a polymeric sample substrate having a reaction site-surface and a substrate surface. The fluorescence reader includes a light source arranged to illuminate the reaction site-surface through the substrate surface, and a detector device arranged to detect fluorescent light emitted from the reaction site-surface and transmitted through the substrate surface, the substrate surface being configured to increase transmission of emitted fluorescent light by suppression of total internal reflection.Type: ApplicationFiled: March 31, 2014Publication date: July 31, 2014Applicant: Johnson & Johnson ABInventors: Tomas Lindstrom, Ib Mendel-Hartvig, Ove Öhman, Johan Backlund, Kennet Vilhelmsson
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Patent number: 8759115Abstract: An assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label. The device includes a substrate surface having a sample addition zone, a reaction zone and an absorbing zone, the zones being connected by at least one fluid passage, wherein the device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone. Both functionality verifying features are capable of undergoing a detectable change when contacted by the sample, in which the assay device further includes at least one alignment verification zone. There is further provided a kit of parts and a method of conducting an assay.Type: GrantFiled: December 12, 2012Date of Patent: June 24, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Ohman, Ib Mendel-Hartvig, Tomas Lindstrom
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Patent number: 8753585Abstract: A device for handling liquid samples, comprising a flow path with at least one zone for receiving the sample, and a transport or incubation zone, said zones connected by or comprising an area having projections substantially vertical to its surface, said device provided with a sink with a capacity of receiving said liquid sample, said sink comprising an area having projections substantially vertical to its surface, and said sink being adapted to respond to an external influence regulating its capacity to receive said liquid sample.Type: GrantFiled: June 8, 2010Date of Patent: June 17, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Ohman, Ib Mendel-Hartvig
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Patent number: 8722423Abstract: A device and method for the separation of a component in a liquid sample prior to the detection of an analyte in said sample, wherein a sample is added to a receiving zone on a substrate, said substrate further optionally comprising a reaction zone, a transport or incubation zone connecting the receiving and reaction zone, respectively, forming a flow path on a substrate, wherein said substrate is a non-porous substrate, and at least part of said flow path consists of areas of projections substantially vertical to said surface, and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such, that lateral capillary flow of said liquid sample in said zone is achieved, and where means for separation are provided adjacent to the zone for receiving the sample. Said means for separation are chosen among filter means, optionally enhanced by affinity binding and/or aggregation; magnetic means, also optionally enhanced by affinity binding and/or aggregation; and acoustic means.Type: GrantFiled: March 26, 2008Date of Patent: May 13, 2014Assignee: Johnson & Johnson ABInventors: David Bergman, Ib Mendel-Hartvig, Simon Uhrberg
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Patent number: 8691153Abstract: A fluorescence reader for an optical assay arrangement includes a polymeric sample substrate having a reaction site-surface and a substrate surface. A light source is arranged to illuminate the reaction site-surface through the substrate surface, and a detector device is arranged to detect fluorescent light emitted from the reaction site-surface and transmitted through the substrate surface, the substrate surface provided, for example, as a light-collecting body to allow fluorescent light rays exceeding a critical emission angle for total internal reflection to escape the substrate and enter the body.Type: GrantFiled: March 22, 2007Date of Patent: April 8, 2014Assignee: Johnson & Johnson ABInventors: Tomas Lindstrom, Ib Mendel-Hartvig, Ove Öhman, Johan Backlund, Kennet Vilhelmsson