Abstract: The method of this invention relates to the use of improved anchor primers and a novel purification process to increase the efficiency and accuracy of the differential display technique.

Abstract: There is disclosed a method for the treatment of fungal diseases in nails, which comprises the topical administration to the nail and, if desired, also to the surrounding skin, of (1) a sulfhydryl containing amino acid or a derivative thereof, the pharmaceutically acceptable salts or esters thereof, or stereoisomers thereof, (2) urea, (1) and (2) being administered in an amount sufficient to enhance the permeation of antifungal drugs through nail tissue, either prior to or, preferably, concurrently with the topical administration to the nail of (3) an effective amount of an antifungal drug.

Abstract: Entirely anhydrous topical preparations comprising (I) propylene carbonate, (II) one or more short carbon-chain alcohols and/or glycols including ethanol, isopropyl alcohol, propylene glycol, butylene glycol, polyethylene glycol, hexylene glycol, methoxypolyethylene glycol, and (III) either or both of glycerol and one or more therapeutically or cosmetically active ingredients.

Abstract: Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability. More particularly, said skin care compositions contain (a) an emulsifier system selected from the group consisting of: (i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate; (ii) cetearyl alcohol and cetearyl glucoside; (iii) a mixture of a polyethylene glycol ethers of stearyl alcohol; and (iv) a mixture of sorbitan stearate and polysorbate 60; (b) a co-emulsifier selected from the group consisting of cetyl alcohol, stearyl alcohol and mixtures thereof; (c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition which contains (i) a light, dry absorbable oil and (ii) substantive, emollient oils or waxes, wherein the light, dry absorbable oil and the substantive oil or wax are present in a ratio of from about 1:3 for about 10:1.

Abstract: This invention relates to compositions and methods for treating the skin containing retinoids and alpha hydroxy acids such as latic acid, malic acid, fruit acids and sugar-cane-derived acids, for mitigating the irratating effects of retinoids on the skin.

Abstract: The present invention relates to a clear colorless soap bar with superior mildness, lathering and discoloration resistance. The clear colorless soap consists of a blend of C12-C18 fatty acids neutralized with sodium hydroxide (NaOH) and triethanolamine (TEA). Excess TEA acts as a co-solvent and is responsible for clarity of the soap bar. The bar also contains a branched chain acid such as isostearic acid to break up crystallinity and add to product clarity. Low color and color stability are obtained by removing unsaturated fatty acids, and by the use of antioxidants (BHT and Vitamin E). Low levels of C6 to C10 fatty acids provide exceptional mildness.

Abstract: This invention relates to a liquid composition for personal cleansing and hydrating of human skin containing a cleaning agent such as an anionic, amphoteric or non-ionic surfactant, and a hydrating agent such as glycerol. The compositions of this invention substantially block transepidermal water loss.

Abstract: A water resistant, flexible, dermal adhesive product for conformable topical application to human skin, the dermal adhesive product comprising a backing sheet having an adhesive for removably adhering the sheet to the skin, wherein the adhesive is a highly crosslinked pressure sensitive adhesive composition comprising the polymerization reaction product of about 75% to about 95% of a mixture of at least two alkyl acrylate or methacrylate esters, about 1% to about 10% ethylenically unsaturated carboxylic acid, and about 10% to about 20% vinyl lactam, by dry weight of solids, preferably about 80% to about 90% of a mixture of at least two alkyl acrylate or methacrylate esters, about 2% to about 5% ethylenically unsaturated carboxylic acid, and about 10% to about 20% vinyl lactam, by dry weight of solids.

Abstract: This invention relates to personal lubricant compositions that are at least between three and eighteen times more lubricious than the compositions known previously. The compositions of this invention contain one or more polyhydric alcohols, one or more water-soluble polymers derived from cellulose, water and, optionally, preservatives and alkali metal or alkaline earth metal bases. The compositions of this invention can provide a vehicle for delivering medicaments for contraception and for the treatment and prevention of disease. This invention also relates to methods of using the personal lubricant compositions of this invention.

Abstract: The invention provides for skin cleanser and astringent compositions comprising an oil-absorbing powder, a thickening agent, a keratolytic agent and an alcohol. The compositions also comprise water, fragrances, colorants, an emollient and a humectant.