Abstract: The general disclosure discusses a system and method for improving the efficacy of blood filtration treatments such as hemodialysis, hemofiltration, and hemodiafiltration. More particularly, the disclosure discusses a microfluidic device that includes first and second channels separated by a permeable membrane. One of the channels is configured for blood flow and includes a protein gel disruption layer. The protein gel disruption layer includes a plurality of elements at least partially extending across the blood flow channel that reduce the formation of a boundary layer or gel layer at the blood-membrane interface.
Type:
Grant
Filed:
September 16, 2014
Date of Patent:
March 21, 2017
Assignee:
Johnson & Johnson Innovation LLC
Inventors:
Jeffrey T. Borenstein, Joseph L. Charest, Chris DiBiasio, Violet Finley