Abstract: The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in particular, modulating cellular activity via the modulation of signal transduction. More particularly, the present invention relates to human sphingosine kinase and to derivatives, analogues, chemical equivalents and mimetics thereof. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications.
Type:
Application
Filed:
September 26, 2006
Publication date:
March 29, 2007
Applicant:
Johnson & Johnson Pharmaceutical R and D LLC
Inventors:
Stuart Pitson, Brian Wattenberg, Pu Xia, Richard D'Andrea, Jennifer Gamble, Matthew Vadas
Abstract: The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in particular, modulating cellular activity via the modulation of signal transduction. More particularly, the present invention relates to human sphingosine kinase and to derivatives, analogues, chemical equivalents and mimetics thereof. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications.
Type:
Application
Filed:
August 18, 2003
Publication date:
July 8, 2004
Applicant:
Johnson & Johnson Pharmaceutical R and D LLC
Inventors:
Stuart Maxwell Pitson, Brian Wolff Wattenberg, Pu Xia, Richard James D'Andrea, Jennifer Ruth Gamble, Matthew Alexander Vadas