Abstract: A multimodal airborne pathogen control apparatus and system configured to direct and decontaminate a volume of indoor air of occupied spaces and reduce the risk of spreading airborne contagions. Certain aspects of the multimodal airborne pathogen control apparatus and system may include one or more infection control modalities including, but not limited to, dielectric Cold Plasma generation, non-ozone producing UV-C light, True HEPA filtration comprising a monoterpene phenol-impregnated filter material, and configurable intake/output ducting to direct airflow to/from a desired area and regulate interior atmospheric pressure. Embodiments of the present disclosure include a door-mounted control unit comprising a door panel having one or more directional intake vents at a floor-level of the door panel, an interior chamber housing a blower fan and one or more germicidal irradiation/inactivation means, and one or more directional output vents at a head level of the door panel.