Patents Assigned to Joslin Diebetes Center
  • Methods of treating, reducing, or preventing autoimmune conditions
    Patent number: 7973016
    Abstract: The present invention relates to methods and kits for treating, reducing, or preventing autoimmune conditions such as rheumatoid arthritis by administering to a mammal in need thereof an agent that modulates the expression level or biological activity of Toll-like receptor-9 (TLR-9). Also disclosed are screening methods that make use of TLR-9 for the identification of novel therapeutics for autoimmune conditions.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: July 5, 2011
    Assignee: Joslin Diebetes Center
    Inventors: Diane Mathis, Christophe O. Benoist, Hsin-Jung Wu