Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
Type:
Application
Filed:
January 12, 2012
Publication date:
May 17, 2012
Applicant:
JOULE UNLIMITED TECHNOLOGIES, INC.
Inventors:
David A. Berry, Dan E. Robertson, Frank A. Skraly, Brian D. Green, Christian P. Ridley, Sriram Kosuri, Nikos B. Reppas, Martha Sholl, Noubar B. Afeyan
Abstract: The present disclosure identifies methods and compositions for modifying microbial cells, such that the organisms efficiently synthesize terminal olefins, and in particular the use of such organisms for the commercial production of propylene and related molecules.
Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.
Type:
Application
Filed:
December 22, 2011
Publication date:
April 19, 2012
Applicant:
JOULE UNLIMITED TECHNOLOGIES, INC.
Inventors:
Nikos Basil Reppas, Christian Perry Ridley
Abstract: This disclosure pertains to the functional localization of heterologous integral plasma membrane proteins (HIPMPs) lacking cleavable signal sequences into the plasma membrane (PM) of cyanobacterial hosts, e.g., JCC138 (Synechococcus sp. PCC 7002) or an engineered derivative thereof. More specifically, the disclosure provides chimeric integral plasma membrane proteins comprising pseudo leader sequences (PLSs) that promote increased hydrocarbon (e.g., alkane) export capabilities when expressed in a photosynthetic organism, e.g., a cyanobacterium.
Abstract: The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
Type:
Application
Filed:
September 21, 2011
Publication date:
March 29, 2012
Applicant:
JOULE UNLIMITED TECHNOLOGIES, INC.
Inventors:
George Church, Frank A. Skraly, Brian D. Green, Jacob C. Harrison
Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.
Type:
Grant
Filed:
March 18, 2011
Date of Patent:
January 24, 2012
Assignee:
Joule Unlimited Technologies, Inc.
Inventors:
Nikos Basil Reppas, Christian Perry Ridley
Abstract: The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium.
Type:
Application
Filed:
September 23, 2011
Publication date:
January 19, 2012
Applicant:
JOULE UNLIMITED TECHNOLOGIES, INC.
Inventors:
Brian Green, Nikos Reppas, Dan Robertson
Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.
Type:
Application
Filed:
September 23, 2011
Publication date:
January 12, 2012
Applicant:
JOULE UNLIMITED TECHNOLOGIES, INC.
Inventors:
Nikos Basil Reppas, Christian Perry Ridley
Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms, such that the organisms efficiently convert carbon dioxide and light into compounds such as esters and fatty acids. In certain embodiments, the compounds produced are secreted into the medium used to culture the organisms.
Type:
Application
Filed:
September 23, 2011
Publication date:
January 12, 2012
Applicant:
JOULE UNLIMITED TECHNOLOGIES, INC.
Inventors:
David Arthur Berry, Noubar Boghos Afeyan, Frank Anthony Skraly, Christian Perry Ridley, Dan Eric Robertson, Regina Wilpiszeski, Martha Sholl
Abstract: The present invention provides fractional condensation apparatuses, systems and methods that can recover volatile products from highly diluted liquid and vapor feed mixtures with high purity and recovery yield, both in batch and continuous distillation, while being also designed to achieve low-cost and efficient recovery processes. Single apparatuses and columns can be connected to each other to expand or shrink the column length for desired separation. The apparatuses, systems and methods can be applied to separate mixtures with both narrow and wide boiling point ranges.
Abstract: The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium.
Type:
Grant
Filed:
June 22, 2011
Date of Patent:
November 1, 2011
Assignee:
Joule Unlimited Technologies, Inc.
Inventors:
Brian Green, Nikos Reppas, Dan Robertson
Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms, such that the organisms efficiently convert carbon dioxide and light into compounds such as esters and fatty acids. In certain embodiments, the compounds produced are secreted into the medium used to culture the organisms.
Type:
Grant
Filed:
September 3, 2010
Date of Patent:
November 1, 2011
Assignee:
Joule Unlimited Technologies, Inc.
Inventors:
David Arthur Berry, Noubar Boghos Afeyan, Frank Anthony Skraly, Christian Perry Ridley, Dan Eric Robertson, Regina Wilpiszeski, Martha Sholl
Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.
Type:
Grant
Filed:
May 2, 2011
Date of Patent:
October 25, 2011
Assignee:
Joule Unlimited Technologies, Inc.
Inventors:
Nikos Basil Reppas, Christian Perry Ridley
Abstract: The present invention provides fractional condensation apparatuses, systems and methods that can recover volatile products from highly diluted liquid and vapor feed mixtures with high purity and recovery yield, both in batch and continuous distillation, while being also designed to achieve low-cost and efficient recovery processes. Single apparatuses and columns can be connected to each other to expand or shrink the column length for desired separation. The apparatuses, systems and methods can be applied to separate mixtures with both narrow and wide boiling point ranges.