Abstract: The present invention provides a method and a kit for determining the risk or rate of an individual of developing diabetes related cardiovascular complications in a subject suffering from either type 1 diabetes mellitus or type 2 diabetes mellitus. The method and the kit comprises: determining the levels of two or more biomarkers purified from a biological sample; wherein said biomarkers are selected from the group comprising lysine advanced glycation end products, arginine advanced glycation end products, and oxidation products; and comparing the determined biomarker levels to standard values, wherein the level of said biomarkers indicate the risk or rate of developing diabetes related cardiovascular disease.