Patents Assigned to Jouveinal
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Patent number: 6573431Abstract: The invention concerns the use of recombinant nucleotides sequences containing cDNA coding for a preduodenal lipase, or any sequence derived from this cDNA, for transforming plant cells in order to obtain recombinant preduodenal lipase or polypeptide derivatives. The invention also concerns the use of genetically modified plants or parts thereof, or extracts of these plants or the use of recombinant preduodenal lipase or résultant polypeptide derivatives in the field of foodstuffs, or for producing medicaments, or in industry.Type: GrantFiled: July 2, 1999Date of Patent: June 3, 2003Assignees: Biochem S.A., Jouveinal S.A.Inventors: Philippe Lenee, VĂ©ronique Gruber, Sylvie Baudino, Bertrand Merot, Claude Benicourt, Claire Cudrey
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Patent number: 5972927Abstract: Diazepinoindoles of formula (I), ##STR1## wherein A is mono- to trisubstituted aryl or heteroaryl, and B is an --OR.sub.1 or --NR.sub.2 R.sub.3 group where R.sub.1, R.sub.2 and R.sub.3 are particularly hydrogen, and racemic forms, enantiomers and pharmaceutically acceptable salts thereof, as phosphodiesterase IV inhibitors, are disclosed.Type: GrantFiled: October 20, 1998Date of Patent: October 26, 1999Assignee: JouveinalInventors: Yves Pascal, Henry Jacobelli, Alain Calvet, Adrian Payne, Svein G. Dahl
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Patent number: 5852190Abstract: The invention relates to diazepinoindoles of formula: ##STR1## in which R is hydrogen, lower alkyl or lower alkoxy; A is aryl or nitrogen-containing heteroaryl, each of which is optionally substituted by from one to three groups of halogen, lower alkyl, haloalkyl, lower alkoxy and acetamido, or their racemic forms, isomers or pharmaceutically acceptable salts, wherein for the racemic forms of the (S) configuration, A is not phenyl, haloalkyl, or 2-indolyl when R is hydrogen, and for the racemic forms of the (R) configuration, A is not 2-indolyl when R is hydrogen. Also, the invention relates to a method for inhibiting cyclic nucleotide phosphodiesterase activity by administering these compounds to a subject in an amount which is therapeutically effective to inhibit cyclic nucleotide phosphodiesterase activity.Type: GrantFiled: February 22, 1995Date of Patent: December 22, 1998Assignee: Institut de Recherche Jouveinal SAInventors: Yves Pascal, Indres Moodley, Alain Calvet, Jean-Louis Junien
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Patent number: 5849760Abstract: New 2-(arylalkenyl)azacycloalkane derivatives which are ligands for sigma receptors, of the formula (I) ##STR1## in which: Ar is aryl or heteroaryl, optionally mono- to trisubstituted,m has the value 1 or 2,n has the value 1 to 3,R is phenyl, or cycloalkyl containing 3 to 7 carbon atoms,their isomers and their addition salts. Medicinal drugs which are antipsychotic agents and are useful in gastroenterology.Type: GrantFiled: June 7, 1996Date of Patent: December 15, 1998Assignee: Institut de Recherche JouveinalInventors: Alain Pierre Calvet, Henry Jacobelli, Jean-Louis Junien, Pierre Riviere, Fran.cedilla.ois-Joseph Roman
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Patent number: 5807726Abstract: The present invention relates to dog gastric lipase as obtained by genetic engineering as well as to the nucleotide sequence encoding this recombinant DGL. It also relates to the use of this recombinant DGL for the production of pharmaceutical compositions intended especially for the treatment of pathologies linked to the insufficiency, or even the absence, of secretion of lipases in the body of an individual.Type: GrantFiled: April 13, 1994Date of Patent: September 15, 1998Assignee: Institut de Recherche Jouveinal, S.A.Inventors: Claire Blanchard, Claude Benicourt, Jean-Louis Junien
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Patent number: 5472970Abstract: Allylaminoesters of the formula (I): ##STR1## in which: R.sub.1 is H or low-molecular-weight alkyl,R.sub.2 is low-molecular-weight alkyl, cycloalkyl, or low-molecular-weight phenylcycloalkyl, pyridyl or phenyl, low-molecular-weight phenylalkyl, low-molecular-weight diphenylalkyl, low-molecular-weight phenylalkenyl, in which the phenyl cycle may be mono-, di- or trisubstituted by chlorine atoms, low-molecular-weight alkyl radicals, low-molecular-weight alkoxy, or trifluoromethyl, acetamide or acetyloxy radicals, their racemic forms, their (S) enantiomers and their addition salts. Also, antiallergic drugs containing the same.Type: GrantFiled: September 19, 1994Date of Patent: December 5, 1995Assignee: Institut de Recherche Jouveinal S.A.Inventors: Alain P. Calvet, Agnes G. Grouhel, Jean-Louis Junien
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Patent number: 5389686Abstract: Process for the treatment of painful syndromes, especially local and/or visceral, consisting in the parenteral or topical administration of a therapeutically effective quantity of the (-) tartrate of (+)-(R)-1-[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-prop ylamine.Type: GrantFiled: July 13, 1993Date of Patent: February 14, 1995Assignee: Jouveinal SAInventors: Laurent Diop, Agnes Grouhel, Jean-Louis Junien, Annick Langlois, Xavier Pascaud
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Patent number: 5348980Abstract: Enantiomers of (S) configuration of formula (I) ##STR1## in which R is H or methyl, with antiallergic and in particular antihistaminic activity, useful as medicinal products.Type: GrantFiled: May 3, 1993Date of Patent: September 20, 1994Assignee: Institute de Recherche JouveinalInventors: Gilbert Aubard, Jacques Bure, Alain Calvet, Claude J. Gouret, Agnes Grouhel, Jean-Louis Junien
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Patent number: 5326784Abstract: New cycloalkylalkylamines which are sigma-receptor ligands of formule (I) ##STR1## in which: R.sub.1 is H or lower alkyl; X and Y are H, OH, lower alkyl, lower alkoxy, halogen or nitrile; V.sub.1 and V.sub.2 together form a double bond attached to an oxygen atom or to a hydroxyimino radical, or are linked as an ethylenedioxy chain; A represents a valency bond, an oxygen atom, a methylene or an ethylene group; m is equal to 0, 1 or 2; n has the value of an integer from 1 to 5. Psychotropic drug which is also useful in gastroenterology.Type: GrantFiled: July 29, 1993Date of Patent: July 5, 1994Assignee: Institut de Recherche JouveinalInventors: Jean-Louis Junien, Alain Calvet, Henri Jacobelli, Francois Roman
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Patent number: 5326878Abstract: Method of resolution of chiral hydantoins of the general formula I ##STR1## in which: R.sub.1 designates a lower alkyl radical comprising 1 to 5 carbon atoms in linear or branched chain,R.sub.2 designates a phenyl radical, possibly mono-, di-, or tri-substituted by lower alkyl or alkoxy radicals or halogen atoms, whether identical of different, or a heteroaryl radical containing a ring of 5 to 7 members in which the sole hetero atom is nitrogen, oxygen or sulfur, or else an aralkyl radical the alkyl part of which comprises one or two carbon atoms and the aryl ring is a phenyl group possibly mono-, di- or tri-substituted by radicals which are lower alkyl or alkoxy radicals or halogen atoms, whether identical or different. The hydantoin (I) to be resolved is dissolved in an alcohol or an alkaline solution, and an enantiomer of .alpha.Type: GrantFiled: July 21, 1992Date of Patent: July 5, 1994Assignee: Jouveinal SAInventors: Dominique Depernet, Roger Bouaziz, Gerard Coquerel, Marie N. Petit
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Patent number: 5266599Abstract: (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylam ine of formula ##STR1## is a medicament of use in gastroenterology.Type: GrantFiled: August 19, 1992Date of Patent: November 30, 1993Assignee: Jouveinal S.A.Inventors: Gilbert G. Aubard, Alain P. Calvet, Agnes Grouhel, Henri Jacobelli, Jean-Louis Junien, Xavier B. Pascaud, Francois J. Roman
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Patent number: 5245080Abstract: (+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylam ine of formula ##STR1## is a medicament of use in gastroenterology.Type: GrantFiled: August 19, 1992Date of Patent: September 14, 1993Assignee: Jouveinal SAInventors: Gilbert G. Aubard, Alain A. Calvet, Henri Jacobelli, Jean-Louis Junien, Xavier B. Pascaud
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Patent number: 5236947Abstract: The present invention relates to propanamines of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted in an identical or different manner with halogen atoms, or lower alkyl, lower haloalkyl or lower alkoxy radicals;R2 is a lower alkyl radical,R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkyalkyl radical,R5 is a 5-to 7-membered cycloalkyl radical or a phenyl radical, andW represents a heterocycle .dbd.C[Q--(CH.sub.2).sub.n --Q] in which Q is an oxygen or sulfur atom and n is 2 or 3,and their acid addition salts with pharmaceutically acceptable acids. The invention also relates to antidiarrheal pharmaceutical compositions comprising the claimed propanamines.Type: GrantFiled: June 17, 1992Date of Patent: August 17, 1993Assignee: Jouveinal S.A.Inventors: Alain Calvet, Agnes Grouhel, Henri Jacobelli, Jean-Louis Junien, Xavier Pascaud
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Patent number: 5143938Abstract: A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted,or is a 5- or 6-membered monocyclic heteroaryl radical in which the single heteroatom is nitrogen, oxygen or sulfur,R2 is a lower alkyl radical,R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkylalkyl radical,or, together with the nitrogen atom to which they are attached, form a saturated 5- to 6-membered heterocycle comprising only one heteroatom,R5 is a 5- to 7-membered cycloalkyl radical, a phenyl radical or a 5- or 6-membered monocyclic heteroaryl radical,and W representsa group .dbd.CH--QH,or a heterocycle .dbd.C[Q--(CH2)n--Q],or a group .dbd.C.dbd.Q, in which groupsQ is an oxygen or sulfur atom,n has the value 2 or 3,W being .dbd.C.dbd.Q only when R3 and R4 are not both hydrogen, and their additions salts with pharmaceutically acceptable acids.Type: GrantFiled: February 26, 1991Date of Patent: September 1, 1992Assignee: Jouveinal S.A.Inventors: Alain Calvet, Agnes Grouhel, Henri Jacobelli, Jean-Louis Junien, Xavier Pascaud
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Patent number: 5089639Abstract: N-Cycloalkylalkylamines of formula I: ##STR1## in which: R1 is phenyl which is optionally mono-, di- or trisubstituted by halogens or lower alkyl, haloalkyl or lower alkoxy radicals, or is an aromatic heterocyclic radical having 5 to 7 chain members, in which the hetero atom is nitrogen, oxygen or sulphur,R2 is lower alkyl,R3 is hydrogen or lower alkyl,m has the value of 1 or 2,R4 is cycloalkyl --CH(CH2)n, in which a carbon atom may carry a radical Rx, which is lower alkyl or phenyl; and in which n has the values from 2 to 5,R5 is phenyl, which can be mono-, di- or trisubstituted by halogens or by lower alkoxy radicals, andQ represents an ethylene-1,2-diyl group --CH.dbd.Type: GrantFiled: January 24, 1991Date of Patent: February 18, 1992Assignee: Jouveinal S.A.Inventors: Gilbert G. Aubard, Alain P. Calvet, Jean-Pierre Defaux, Claude J. Gouret, Agnes M. Grouhel, Henry L. Jacobelli, Jean-Louis Junien, Xavier B. Pascaud, Francois F. Roman, James P. Hudspeth, Yuan Lin
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Patent number: 5082937Abstract: Benzodiazepines of formula ##STR1## in which R.sup.9 is hydrogen or chlorine, R10 is phenyl, possibly substituted, R11 is hydrogen, R12 is oxygen or sulphur, R13 is an NH group, Ar is aromatic or heteroaromatic comprising one or more rings and in which, in particular, A is an ethylene or trimethylene bridge; e is 1 or 2; which are gastrin antagonists and/or central antagonists of cholecystokinin.Type: GrantFiled: September 18, 1990Date of Patent: January 21, 1992Assignee: Jouveinal S.A.Inventors: Alain P. Calvet, Jean-Louis Junien, Yves R. Pascal, Xavier B. Pascaud, Francois J. Roman
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Patent number: 5075231Abstract: Process for the preparation of a gastric lipase. The stomachs of rabbits or horses undergo extraction by an acid aqueous medium, the lipase extract is salted out by the addition of hydrosoluble salts then, by filtration on a molecular sieve, followed by separation using ion exchange chromatography, an elution fraction containing the lipase is collected.Medicament for fighting against malabsorptions of fatty substances.Type: GrantFiled: September 17, 1987Date of Patent: December 24, 1991Assignee: Jouveinal S.A.Inventors: Herve Moreau, Robert Verger, Daniel Lecat, Jean-Louis Junien
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Patent number: 5021408Abstract: 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflamatory agents.Type: GrantFiled: July 9, 1987Date of Patent: June 4, 1991Assignee: Jouveinal S.A.Inventors: Gilbert G. Aubard, Agnes G. Grouhel, Jean-Louis Junien, Claude P. Roux, Dieran R. Torossian
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Patent number: 5017723Abstract: Substituted ethylamines of the formula ##STR1## wherein R.sub.1 is phenyl optionally mono-, di- or trisubstituted by halogen, lower alkyl, lower haloalkyl or lower alkoxy, or is an aromatic heterocycle having 5 to 7 chains wherein the heteroatom is nitrogen, oxygen or sulfur,R.sub.2 is lower alkyl,R.sub.3 and R.sub.4, each independently, represent hydrogen, lower alkyl or lower alkenyl,R.sub.5 is phenyl optionally mono-, di- or trisubstituted by halogen or lower alkoxy or is an aromatic heterocycle having 5 to 7 chains wherein the heteroatom is nitrogen, oxygen or sulfur andQ represents a --CH.dbd.CH-- ethylene group or a 1,2-diyl ##STR2## propane group, their acid addition salts and their optically active forms. These substituted ethylamines have psycotropic properties and are useful as medicines.Type: GrantFiled: February 26, 1990Date of Patent: May 21, 1991Assignee: Jouveinal S.A.Inventors: Gilbert G. Aubard, Alain P. Calvet, Claude J. Gouret, Agnes M. Grouhel, Henry L. Jacobelli, Jean-Louis Junien, Xavier B. Pascaud, Francois J. Roman, Claude D. Soulard, James P. Hudspeth, Yuan Lin
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Patent number: 4994617Abstract: Aminoalcohols of formula: ##STR1## in which R.sub.1 is alkyl, R.sub.2 H or alkyl, R.sub.3 in particularly H, alkyl, phenylakyl, alkanoyl, phenylalkanoyl, in which N, R.sub.2 and R.sub.3 together form a heterocycle saturated with 5 to 7 chain links.Analgesic medicaments.Type: GrantFiled: December 26, 1989Date of Patent: February 19, 1991Assignee: Jouveinal S.A.Inventors: Gilbert Aubard, Jacques Bure, Alain P. Calvet, Claude Gouret, Agnes G. Grouhel, Jean-Louis Junien