Patents Assigned to Joyant Pharmaceuticals, Inc.
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Patent number: 8846734Abstract: Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.Type: GrantFiled: November 25, 2013Date of Patent: September 30, 2014Assignee: Joyant Pharmaceuticals, Inc.Inventors: Qi Wei, Ming Zhou, Xiaoming Xu, Charles Caldwell, Susan Harran, Lai Wang
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Publication number: 20140127155Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.Type: ApplicationFiled: January 16, 2014Publication date: May 8, 2014Applicant: JOYANT PHARMACEUTICALS, INCInventors: Gunnar Hanson, Haizho Sun
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Publication number: 20140100193Abstract: Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.Type: ApplicationFiled: November 25, 2013Publication date: April 10, 2014Applicant: Joyant Pharmaceuticals, Inc.Inventors: Qi Wei, Ming Zhou, Xiaoming Xu, Charles Caldwell, Susan Harran, Lai Wang
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Patent number: 8642554Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.Type: GrantFiled: April 11, 2008Date of Patent: February 4, 2014Assignee: Joyant Pharmaceuticals, Inc.Inventors: Gunnar Hanson, Haizhou Sun
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Patent number: 8592469Abstract: Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.Type: GrantFiled: April 15, 2012Date of Patent: November 26, 2013Assignee: Joyant Pharmaceuticals, Inc.Inventors: Qi Wei, Ming Zhou, Xiaoming Xu, Charles Caldwell, Susan Harran, Lai Wang
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Patent number: 8586542Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.Type: GrantFiled: June 28, 2012Date of Patent: November 19, 2013Assignee: Joyant Pharmaceuticals, Inc.Inventors: Gunnar J. Hanson, David Thomas, Nizal Chandrakumar, Susan Harran
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Patent number: 8551955Abstract: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.Type: GrantFiled: October 28, 2010Date of Patent: October 8, 2013Assignee: Joyant Pharmaceuticals, Inc.Inventors: Haizhou Sun, Xiaoming Xu, Ming Zhou, Susan Harran, Gunnar James Hanson, Lai Wang
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Patent number: 8476256Abstract: Novel diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.Type: GrantFiled: March 26, 2012Date of Patent: July 2, 2013Assignee: Joyant Pharmaceuticals, Inc.Inventors: Gunnar James Hanson, Ming Zhou, Qi Wei, Charles Caldwell
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Patent number: 8426136Abstract: The invention provides a method for determining sensitivity of a cell population to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, which method comprises assaying for an epigenetic modification at the TNF? locus in the cell population as compared to the TNF? locus in a cell population not sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, wherein the presence of the epigenetic modification indicates that the cell population is sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs.Type: GrantFiled: March 31, 2010Date of Patent: April 23, 2013Assignee: Joyant Pharmaceuticals, Inc.Inventors: Lai Wang, Brandon L. Probst
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Patent number: 8334311Abstract: Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.Type: GrantFiled: July 25, 2011Date of Patent: December 18, 2012Assignee: Joyant Pharmaceuticals, Inc.Inventors: Gunnar James Hanson, Qi Wei, Charles Caldwell, Ming Zhou, Lai Wang, Susan Harran
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Patent number: 8299268Abstract: This invention relates to novel macrocyclic lactams intermediates useful for the preparation of diazonamide analogs. This invention also relates to a novel electrochemical oxidative cyclization for the preparation of such macrocyclic lactams, and their further elucidation to provide diazonamide analogs.Type: GrantFiled: July 19, 2011Date of Patent: October 30, 2012Assignees: Board of Regents, The University of Texas System, Joyant Pharmaceuticals, Inc.Inventors: Gunnar Hanson, Charles Caldwell, Patrick G. Harran, Susan Harran, Qi Wei, Ming Zhou
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Patent number: 8222291Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.Type: GrantFiled: October 4, 2010Date of Patent: July 17, 2012Assignee: Joyant Pharmaceuticals, Inc.Inventors: Gunnar J. Hanson, David Thomas, Nizal Chandrakumar, Susan Harran
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Patent number: 8153619Abstract: Novel diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.Type: GrantFiled: May 22, 2009Date of Patent: April 10, 2012Assignee: Joyant Pharmaceuticals, Inc.Inventors: Gunnar James Hanson, Ming Zhou, Qi Wei, Charles Caldwell
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Patent number: 7989482Abstract: Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.Type: GrantFiled: April 29, 2009Date of Patent: August 2, 2011Assignee: Joyant Pharmaceuticals, Inc.Inventors: Gunnar James Hanson, Qi Wei, Charles Caldwell, Ming Zhou, Lai Wang, Susan Harran
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Patent number: 7982051Abstract: This invention relates to novel macrocyclic lactams intermediates useful for the preparation of diazonamide analogs. This invention also relates to a novel electrochemical oxidative cyclization for the preparation of such macrocyclic lactams, and their further elucidation to provide diazonamide analogs.Type: GrantFiled: October 3, 2010Date of Patent: July 19, 2011Assignees: Board of Regents, The University of Texas System, Joyant Pharmaceuticals, Inc.Inventors: Gunnar Hanson, Charles Caldwell, Patrick G. Harran, Susan Harran, Qi Wei, Ming Zhou
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Patent number: 7960420Abstract: Diazonamide A analogs, and the salts, esters and conjugates thereof, having improved aqueous solubility are provided. Also provided are pharmaceutical compositions, and methods for preparing and using such compounds and compositions for the treatment of proliferative diseases.Type: GrantFiled: December 19, 2008Date of Patent: June 14, 2011Assignee: Joyant Pharmaceuticals, IncInventors: Gunnar James Hanson, Qi Wei, Ming Zhou
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Patent number: 7851620Abstract: This invention relates to novel macrocyclic lactams intermediates useful for the preparation of diazonamide analogs. This invention also relates to a novel electrochemical oxidative cyclization for the preparation of such macrocyclic lactams, and their further elucidation to provide diazonamide analogs.Type: GrantFiled: June 6, 2008Date of Patent: December 14, 2010Assignees: Board of Regents, The University of Texas System, Joyant Pharmaceuticals, Inc.Inventors: Gunnar Hanson, Charles Caldwell, Patrick G. Harran, Susan Harran, Qi Wei, Ming Zhou
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Patent number: 7807699Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.Type: GrantFiled: March 21, 2007Date of Patent: October 5, 2010Assignee: Joyant Pharmaceuticals, Inc.Inventors: Gunnar J. Hanson, David Thomas, Nizal Chandrakumar, Susan Harran
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Publication number: 20090104151Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.Type: ApplicationFiled: April 11, 2008Publication date: April 23, 2009Applicant: Joyant Pharmaceuticals, IncInventors: Gunnar HANSON, Haizhou SUN