Abstract: The present disclosure relates to novel DNA aptamers and use thereof. In particular, the present disclosure relates to DNA aptamers selected from a DNA library using Cell-SELEX to bind specifically to cancer cells. The DNA aptamers of the present disclosure selected and optimized for high binding affinity to cancer cells can be effectively used for the diagnosis of cancer as they have enhanced targeting efficiencies for target cells and tissues.
Type:
Application
Filed:
July 19, 2019
Publication date:
August 18, 2022
Applicants:
NATIONAL CANCER CENTER, JP BIO A INC.
Inventors:
Yun Hee KIM, Kyun HEO, Sun II CHOI, In Hoo KIM
Abstract: The present disclosure relates to novel DNA aptamers and use thereof. In particular, the present disclosure relates to DNA aptamers selected from a DNA library using Cell-SELEX to bind specifically to cancer cells. The DNA aptamers of the present disclosure selected and optimized for high binding affinity to cancer cells can be effectively used for the diagnosis of cancer as they have enhanced targeting efficiencies for target cells and tissues as well as high serum stability.
Type:
Application
Filed:
August 8, 2019
Publication date:
March 24, 2022
Applicants:
JP BIO A INC., NATIONAL CANCER CENTER
Inventors:
Yun Hee KIM, Kyun HEO, Sun II CHOI, In Hoo KIM