Patents Assigned to JSC Grindeks
  • 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease
    Patent number: 8940793
    Abstract: 4-[(Haloalkyl)(dimethyl)ammonio]butanoates of formula wherein Hal is Cl or F, n=1 or 2, method for preparing thereof and use thereof for treating cardiovascular disease.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 27, 2015
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Viktors Andrianovs, Marina Makrecka, Daina Gustina, Solveiga Grinberga
  • 4,5-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with nootropic activity
    Patent number: 8791273
    Abstract: The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: July 29, 2014
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvins, Antons Lebedevs, Aleksandrs Cernobrovijs, Maija Dambrova, Liga Zvejniece, Maksims Vorona, Grigorijs Veinbergs
  • USE OF 3-CARBOXY-N-ETHYL-N,N-DIMETHYLPROPAN-1-AMINIUM SALTS IN THE TREATMENT OF CARDIOVASCULAR DISEASE
    Publication number: 20140088125
    Abstract: Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 27, 2014
    Applicant: JSC Grindeks
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Limars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Reinis Vilskersts, Solveiga Grinberga
  • Pharmaceutical combination of 5-fluorouracil and derivate of 1,4-dihydropyridine and its use in the treatment of cancer
    Patent number: 8492413
    Abstract: New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula I wherein R is a lower alkyl group, which is methyl or ethyl R1 and R2 is sodium carboxylate-methyl ester, having synergistic cytotoxic effect combined with 5-fluorouracil.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: July 23, 2013
    Assignee: JSC Grindeks
    Inventors: Gunars Duburs, Egils Bisenieks, Irina Sestakova, Ivars Kalvinsh, Brigita Vigante, Janis Uldrikis, Ilona Domraceva, Elina Jascenko, Janis Poikans, Imanta Bruvere, Ilmars Stonans
  • DERIVATIVES OF 1,4-DIHYDROPYRIDINE POSSESSING ANTIVIRAL EFFICACY
    Publication number: 20130131126
    Abstract: 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type compounds having general formula I wherein R is hydrogen or carboxylate-methyl ester, R1 is sodium carboxylate-methyl ester R2 is methyl, ethyl or sodium carboxyate-methyl ester possessing antiviral efficacy.
    Type: Application
    Filed: July 15, 2011
    Publication date: May 23, 2013
    Applicant: JSC Grindeks
    Inventors: Ilmars Stonans, Ilze Jansone, Indra Jonane-Osa, Egils Bisenieks, Gunars Duburs, Ivars Kalvins, Brigita Vigante, Janis Uldrikis, Imanta Bruvere, Liga Zuka, Janis Poikans, Zaiga Neidere
  • Process for the preparation of 5-(2-ethyl-dihydro-1-inden-2-yl)-1-imidazole and salts thereof
    Patent number: 8431717
    Abstract: The invention provides an improved, highly efficient method for preparing 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole, and its salts, in particular its pharmaceutically acceptable salts.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: April 30, 2013
    Assignee: JSC Grindeks
    Inventors: Viesturs Lusis, Dzintra Muceniece, Inese Reine, Armands Zandersons
  • 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY
    Publication number: 20120215010
    Abstract: The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.
    Type: Application
    Filed: November 4, 2010
    Publication date: August 23, 2012
    Applicant: JSC Grindeks
    Inventors: Ivars Kalvins, Antons Lebedevs, Aleksandrs Cernobrovijs, Maija Dambrova, Liga Zvejniece, Maksims Vorona, Grigorijs Veinbergs
  • Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid
    Patent number: 8119835
    Abstract: A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on “one pot” synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cycloboranes with a subsequent Suzuki-Miyaura coupling with 6-halonaphtenoates and basic hydrolysis of the reaction product in ethylene glycol or 1,2-propanediol.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: February 21, 2012
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvinsh, Aleksandrs Chernobrovijs, Vyacheslav Tribulovich, Vladimir Labeish
  • Method for preparing medetomidine and its salts
    Patent number: 7902377
    Abstract: The invention provides an improved, highly efficient method for preparing Medetomidine, and its salts, in particular its pharmaceutically acceptable salts. The method utilizes the high reactivity of halogenated imidazoles towards transmetalation with Grignard reagents and the subsequent reaction with 2,3-dimethylbenzaldehyde.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: March 8, 2011
    Assignee: JSC Grindeks
    Inventors: Inese Reine, Armands Zandersons