Abstract: A process for one pot synthesis of citalopram is disclosed. The process comprises subjecting 5-cyano phthalide to Grignard reduction followed cyclization and followed by C-alkylation reaction to obtain citalopram without isolation and purification of any intermediates. In another embodiment, 5-cyano phthalide is subjected to sequential Grignard reactions followed by cyclization to obtain citalopram without isolation and purification of any intermediate stages.
Type:
Application
Filed:
February 16, 2004
Publication date:
May 22, 2008
Applicant:
Jubilant Organosys Limted
Inventors:
Ambati Narahari Babu, Vuddamari Srinivas Goud, Santosh Laxman Gaonkar, Sulur G. Manjunatha, Ashok Krishna Kulkarni, Madhari A. Kulkarni