Patents Assigned to JUNCTUCELL BIOMED MANUFACTURING GMBH
  • Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells
    Patent number: 11464806
    Abstract: A method of treating a tumor in a subject including administering a genetically modified mesenchymal stem cell (MSC), wherein the MSC includes one or more exogenous nucleic acid molecule(s), wherein the one or more exogenous nucleic acid molecule(s) includes one or more regions encoding two or more immune response-stimulating cytokines operably linked to one or more promoters or promoter/enhancer combinations, wherein the two or more immune response-stimulating cytokines include at least IL-7, and at least one of IL-12 or IL-21.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: October 11, 2022
    Assignee: JUNCTUCELL BIOMED MANUFACTURING GMBH
    Inventors: Christine Günther, Stefanos Theoharis, Felix Hermann, Ralf Huss