Abstract: The invention relates to novel imaging-based biomarkers for characterizing the structure or function of a human or animal brain. These biomarkers can be a weighted confluency sum score (WCSS) or a percent shielding by brain lesions (SbBL). Methods implementing these biomarkers are also disclosed.
Type:
Grant
Filed:
November 6, 2016
Date of Patent:
May 5, 2020
Assignee:
JUNG DIAGNOSTICS GMBH
Inventors:
Ralph Buchert, Jochen Fiebach, Elisabeth Steinhagen-Thiessen, Kerstin Ritter, Lothar Spies, Joachim Seybold, Per Suppa, Catharina Lange
Abstract: The invention relates to novel imaging-based biomarkers for characterizing the structure or function of a human or animal brain. These biomarkers can be a weighted confluency sum score (WCSS) or a percent shielding by brain lesions (SbBL). Methods implementing these biomarkers are also disclosed.
Type:
Application
Filed:
November 6, 2016
Publication date:
May 11, 2017
Applicant:
JUNG DIAGNOSTICS GMBH
Inventors:
Ralph BUCHERT, Jochen FIEBACH, Elisabeth STEINHAGEN-THIESSEN, Kerstin RITTER, Lothar SPIES, Joachim SEYBOLD, Per SUPPA, Catharina LANGE
Abstract: A method, a software program and a system for processing MRT data of the human brain of a patient, wherein three-dimensional MRT data resolved in voxels of the patient's brain and the brains of a normative database of a plurality of neurologically healthy human individuals are available. The MRT data of the patient's brain are segmented for each voxel into portions of grey substance, white substance and liquor by means of a classification algorithm, wherein for comparison with corresponding data of the normative database the data are normalized before, after or synchronously into a standardized stereotactic space whereby one or more normalized tissue maps result that contain the proportions determined by the classification algorithm, and the tissue map or tissue maps of the patient's brain is or are subjected to a voxel-wise statistical comparison with the correspondingly normalized and segmented data of the normative database.
Abstract: A method, a software program and a system for processing MRT data of the human brain of a patient, wherein three-dimensional MRT data resolved in voxels of the patient's brain and the brains of a normative database of a plurality of neurologically healthy human individuals are available. The MRT data of the patient's brain are segmented for each voxel into portions of grey substance, white substance and liquor by means of a classification algorithm, wherein for comparison with corresponding data of the normative database the data are normalized before, after or synchronously into a standardized stereotactic space whereby one or more normalized tissue maps result that contain the proportions determined by the classification algorithm, and the tissue map or tissue maps of the patient's brain is or are subjected to a voxel-wise statistical comparison with the correspondingly normalized and segmented data of the normative database.