Abstract: The invention relates to a measuring device (10) for measuring physical characteristics of cells. The device (10) comprises: a microfluidic chip (20) provided with a flow channel (22) for allowing cells to flow through; a manipulator (24) configured to apply deformation force to a cell in a continuous flow; and a sensor (26) configured to sense a physical characteristic of the cell. The manipulator (24) and the sensor (26) are configured to define a width (W2) of the flow channel (22) as a gap formed between them. The manipulator (24) is configured to apply the deformation force to the cell by compressing the cell against the sensor (26).
Type:
Grant
Filed:
October 6, 2020
Date of Patent:
May 6, 2025
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), JUNIA
Inventors:
Dominique Collard, Hiroyuki Fujita, Stanislav Karsten, Mehmet Cagatay Tarhan
Abstract: A method for determining a set of physical parameters of a sample, comprising the steps of: —A Retrieving a measured sample temporal trace Es(t), —B retrieving a measured reference temporal trace Eref(t), —C determining an widened reference temporal trace, called Eref0(t), and determining a discrete Fourier transform {hacek over (E)}ref0(?) of the widened reference temporal trace—D determining a modeling of an impulse response of the sample in the frequency domain, depending on the set of physical parameters (pi), called sample frequency model {hacek over (E)}model{Pi}(?), from the Fourier Transform of the widened reference temporal trace {hacek over (E)}ref0(?) and a physical behavior model of the sample, —E applying an optimization algorithm on the set of physical parameters (pi) comprising the sub steps of: —E1 initializing physical parameters (pi), —realizing iteratively the sub steps of: —E2 calculating an inverse discrete Fourier transform of the sample frequency model {hacek over (E)}model{Pi}(?), call
Type:
Grant
Filed:
February 11, 2021
Date of Patent:
July 23, 2024
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRALE LILLE INSTITUT, UNIVERSITE DE LILLE, UNIVERSITE POLYTECHNIQUE HAUTE-DE-FRANCE, JUNIA
Abstract: A phonon parametric oscillator is provided. The phonon parametric oscillator comprises a laser for periodically emitting brief optical pulses (IL), an assembly for generating acoustic pulses (IA) and a medium for coupling the acoustic pulses to an object (O), the assembly for generating acoustic pulses comprising an entrance face, an exit face, a conversion medium for converting the brief optical pulses into acoustic pulses and a propagation medium for propagating said acoustic pulses, the entrance and exit faces being reflective to the acoustic pulses, the propagation medium having a defined thickness, the exit face making contact with the coupling medium. In the phonon parametric oscillator according to the invention, the round-trip time of an acoustic pulse due to reflection from the entrance and exit faces, is equal to the emission period (?) of the laser, so that the reflected acoustic pulse is in phase with the following acoustic pulse.
Type:
Grant
Filed:
February 8, 2019
Date of Patent:
April 2, 2024
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, JUNIA, UNIVERSITE DE LILLE, CENTRALE LILLE INSTITUT
Abstract: The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the treatment of cancer or inflammatory diseases.
Type:
Grant
Filed:
March 29, 2019
Date of Patent:
March 5, 2024
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CHRU DE LILLE, UNIVERSITE COTE D'AZUR, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE LILLE, JUNIA