Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, m and n are as defined in the specification, with an inhibitory effect of PD-L1 expression and an inhibitory effect of reduced production of IL-2 and a medicament useful for the treatment of a disease associated with the reduced immune function caused by the formation of PD-1/PD-L1 binding.
Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
Type:
Grant
Filed:
October 9, 2015
Date of Patent:
October 25, 2016
Assignees:
National University Corporation Okayama University, Junsei Educational Institution
Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
Type:
Application
Filed:
October 9, 2015
Publication date:
February 4, 2016
Applicants:
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, JUNSEI EDUCATIONAL INSTITUTION
Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
Type:
Grant
Filed:
February 22, 2011
Date of Patent:
November 17, 2015
Assignees:
National University Corporation Okayama University, Junsei Educational Institution
Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
Type:
Application
Filed:
February 22, 2011
Publication date:
December 20, 2012
Applicants:
Junsei Educational Institution, National University Corporation Okayama University