Abstract: Disclosed are a fireproof cabinet body structure and a fireproof safety cabinet. The fireproof cabinet body structure comprises a cabinet body, the cabinet body comprises an inner panel, a gypsum board and a keel frame, and the inner panel and the gypsum board are fixedly mounted on two sides of the keel frame. The fireproof safety cabinet comprises a cabinet body and a cabinet door, the cabinet body is provided with an air inlet and an air outlet, ventilation fire-retardant valves are mounted at the air inlet and the air outlet, an inner side of the cabinet body is provided with an air supply opening corresponding to the air inlet and an air return opening corresponding to the air outlet, and the cabinet body is provided with electrostatic grounding bolts connected with the keel frame at the top part and/or side part of the cabinet body.