Patents Assigned to Juvena Therapeutics, Inc.
  • Heparin-Associated Polypeptides and Uses Thereof
    Publication number: 20230405089
    Abstract: Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
    Type: Application
    Filed: February 1, 2023
    Publication date: December 21, 2023
    Applicant: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Jeremy O'Connell, Thach Mai, Rami Jaafar
  • Regenerative Polypeptides and Uses Thereof
    Publication number: 20230398187
    Abstract: Described herein are polypeptides comprising an FGF17, IGF2, or BMP? amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Also described herein are synergistic combinations of a Fibroblast Growth Factor Receptor agonist and a glycosaminoglycan, an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid, and BMP receptor agonists and mTOR activators and/or glycosaminoglycans. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.
    Type: Application
    Filed: December 22, 2020
    Publication date: December 14, 2023
    Applicant: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Jeremy O'Connell, Thach Mai, Rami Jaafar, Zhihua Li
  • Regenerative Polypeptides and Uses Thereof
    Publication number: 20230312663
    Abstract: Described herein are polypeptides comprising an FGF17, IGF2, or BMP7 amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Also described herein are synergistic combinations of a Fibroblast Growth Factor Receptor agonist and a glycosaminoglycan, an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid, and BMP receptor agonists and mTOR activators and/or glycosaminoglycans. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.
    Type: Application
    Filed: February 1, 2023
    Publication date: October 5, 2023
    Applicant: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Jeremy O'Connell, Thach Mai, Rami Jaafar, Zhihua Li
  • Heparin-Associated Polypeptides and Uses Thereof
    Publication number: 20220409696
    Abstract: Described herein are polypeptides comprising an IGF2 amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Mutations within the IGF2 amino acid sequence improved the stability of the molecule by reducing backbone cleavage. Also described herein are synergistic combinations of an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.
    Type: Application
    Filed: June 10, 2022
    Publication date: December 29, 2022
    Applicant: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Jeremy O'Connell, Thach Mai, Zhihua Li
  • Heparin-Associated Polypeptides and Uses Thereof
    Publication number: 20210038693
    Abstract: Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
    Type: Application
    Filed: October 16, 2020
    Publication date: February 11, 2021
    Applicant: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Jeremy O'Connell, Thach Mai
  • Heparin-associated polypeptides and uses thereof
    Patent number: 10821155
    Abstract: Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: November 3, 2020
    Assignee: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Thach Mai, Jeremy O'Connell