Abstract: Expansile hydrogel intraocular lenses are heated above their elastic deformation temperatures and deformed into an elongated configuration having at least one reduced dimension suitable for insertion through a small surgical incision. The lenses are allowed to cool in this configuration and retain the deformed shape prior to surgical implantation. Following implantation the lenses hydrate into an enlarged elastic form reassuming the original lens configuration of full capsule size.

Abstract: Compounds having formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are selected from the group consisting of hydrogen, hydroxy and methoxy. At most one of R.sup.1, R.sup.2 and R.sup.3 and at most one of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is selected from the group consisting of hydroxy and methoxy. M is selected from the group consisting of hydrogen and pharmaceutically acceptable inorganic or organic cations or tautomeric forms thereof. The compounds have immunomodulating activity.

Abstract: The present invention provides an improved intraocular lens haptic having an enlarged anchoring head and an integrally formed support portion extending therefrom. An oblong hole is provided in the anchoring head. The haptic is punched from a sheet or ribbon of polyvinylidene fluoride film, and thereafter a lens optic is cast around the anchoring head. During the casting operation, the lens optic material fills in the oblong hole and all spaces around the anchoring head. Thus, the anchoring head is firmly embedded in an outer periphery of the lens optic. Because the haptic is punched, it can be fabricated to have a variety of different anchoring head shapes and to have a variety of support portion shapes with varying numbers of bends at different bend angles. The orientation of the oblong hole within the anchoring head is also easily changed as is the orientation of the anchoring head relative to the support portion, although both structures are integral and formed from a single sheet of material.

Abstract: An apparatus and method for folding or curling a flexible lens and for inserting the lens into an eye. The apparatus includes a loading and folding head having a slidable tubular member for curling the lens by constricting a loading chamber within the head, a cannula for entering the eye, and a body housing a plunger for advancing the curled lens out of the loading and folding head and through the cannula. The tubular lens-curling member is configured to enable the lens to curl gently in cooperation with a retaining lip on a wall of the loading chamber, in one smooth, simple and continuous motion.

Abstract: A compound of the formula Het--NR--SO.sub.2 --Ph.sup.2 --A--Ph.sup.1 (COOH)(OH) and tautomeric form, salts, solvates, C.sub.1-6 alkyl esters and pharmaceutical compositions of the compound. Ph.sup.1 and Ph.sup.2 are benzene rings with the proviso that carboxy and hydroxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl.The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.

Abstract: In accordance with the disclosed device and method a highly-corrugated hollow miniature torus is introduced into the pupillary opening in the eye of a person. Then, the torus is expanded by introduction of fluid therein, so that it engages and dilates the marginal edge of the iris. An intraocular surgical procedure is then performed, following which the torus is contracted and removed. A valve is employed to control the introduction and discharge of the fluid.

Abstract: The invention relates to ophthalmological compositions for topical treatment of glaucoma or ocular hypertension comprising an effective intraocular pressure reducing amount of a prostaglandin derivative of PGA, PGB, PGD, PGE or PGF, in which the omega chain contains a ring structure, in an ophthalmologically compatible carrier. The invention further relates to the preparation of said compositions and their use for treatment of glaucoma or ocular hypertension.

Abstract: An apparatus and associated method for deforming and inserting a flexible intraocular lens into an eye which permits the size of an ocular incision to be significantly smaller than the diameter of the intraocular lens being implanted, and its embodiments are suitable for use with lenses having radial flange or projecting filament haptics. The apparatus includes a contoured duct with a pair of internal guiding grooves configured to engage peripheral edges of the lens, curling the lens as it is advanced along the longitudinal duct axis from the elongated inlet to the coaxially aligned generally circular outlet of the duct. The guiding grooves are mutually opposed and converge along the length of the duct to essentially the periphery of the duct outlet.

Abstract: The invention relates to the use of hGH, hGRF, hIGF-1, hIGF-2 or analogs of these or a mixture of two or more of these, alone or in conjunction with lactational enhancers for the treatment of human lactation failure. It also relates to the use of hGH, hGRF, hIGF-1, hIGF-2 or analogs of these or a mixture of two or more of these, alone or in conjunction with lactational enhancers for the manufacturing of a medicament for the treatment of human lactation failure, also a profphlactic treatment. Preferably human growth hormone is used. The invention also relates to a method for the treatment of human lactation failure as well as compositions and methods for their manufacturing.

Abstract: The present invention provides an O-Glycosylated Insulin-like Growth Factor 1 (IGF-1) analog of Insulin-like Growth Factor 1, a seventy amino acids single polypeptide chain which displays relatively high homology with proinsulin, essentially free from unglycosylated IGF-1.

Abstract: The invention relates to emulsions intended for parenteral administration and contaning a hydrophobic phase emulsified in a an aqueous phase. In accordance with the invention, a substantial part of the hydrophobic phase contains one or more alkyl esters of pharmacologically acceptable fatty acids, and particularly their ethyl esters. The emulsions can be used for parenteral nutrient supply and as vehicles for pharmacologically active substances or agents and may also be used for both purposes in combination.

Abstract: The invention concerns compounds having the formula I ##STR1## wherein Ar is a phenyl or benzyl group which is optionally substituted with hydroxy or alkoxy;R.sup.1 is hydrogen, lower alkyl, lower alkoxy, hydroxy;R.sup.2 is hydrogen, lower alkyl;R.sup.3 is NR.sup.4 R.sup.5, whereinR.sup.4 and R.sup.5 which can be the same or different, are lower alkyl, or wherein R.sup.4 and R.sup.5, when taken together, form a ring with the nitrogen atom, whereby said ring optionally is substituted with lower alkyl;n is 0 or 1;m is 2 or 3 andtheir salts with physiologically acceptable acids and when the compounds can be in form of optical isomers, the racemic mixture and the individual isomers, for the treatment of disorders of the urinary bladder.

Abstract: A prefilled syringe including a vial containing a measured quantity of an injectable product is provided Adjacent an end the vial is a displaceable wall adapted to be urged by plunger means so as to expel the product from the vial through a needle. The syringe also includes a two part housing for the vial and the plunger. One of the housing parts includes a stop surface that cooperates with a pair of corresponding surfaces extending from an external surface of the plunger. The plunger stop surfaces are positioned on opposite sides of the housing part stop surface to limit the displacement of the plunger within the vial. The position of the stop surfaces on the plunger relative to the vial may be varied by rotating the threadably connected housing parts relative to each other. A click-stop mechanism provided with the housing parts permits the housing parts to be rotated relative to each other in predetermined increments. A graduated dosing ring may be rotatably mounted about the housing parts.

Abstract: A natural antioxidant for stabilizing polyunsaturated oils is disclosed. This oil-soluble antioxidant is prepared by dissolving ascorbic acid in a polar solvent, dissolving phospholipid in a non-polar solvent and then mixing the ascorbic acid solution with the phospholipid solution. After removing the solvent a product is formed which has anti-oxidant properties and is soluble in non-polar solvents.

Abstract: A method is provided for cleansing a protein from multivalent metal ions bound thereto, these ions being released from the protein by exchanging the ions with monovalent metal ions, whereafter the multivalent metal ions are removed. The release and removal of these ions is effected, in particular, by diafiltration or gel filtration processes.

Abstract: The invention is related to the field of treating gastric and duodenal disorders and more specifically to the use of certain 13,14-dihydro-prostaglandin E derivatives, especially of PGE.sub.2, which are modified to contain a ring structure in the omega chain. The invention relates also to pharmaceutical compositions containing an active amount of these derivatives.

Abstract: Intraocular implants having optical lenses that are light, non-toxic, biocompatible, nonleachable in the presence of eye fluids and absorb at least 90% of the ultraviolet light in the 300-380 nm wavelength range but are transparent to most of the visible radiation. The intraocular implants will have a haptic for fixation in the posterior or anterior chamber of the eye. The optical lens has uniformly dispersed therein an ultraviolet light absorbing amount of 2-(hydroxy-lower alkylphenyl) benzotriazole which may be halogen substituted in the 4, 5, 6 or 7 positions.

Abstract: The invention concerns a new process for preparing delmopinol using intermediates having the formula ##STR1## wherein R is 2-propylpentyl optionally with one, two or three internal unsaturated bonds, or 2-substituted-2-propylpentyl optionally with one or two internal unsaturated bonds wherein the 2-substituent is a leaving group.

Abstract: A composition for the prevention of adhesions between body tissues after a surgical operation, containing dextran and hyaluronic acid. The composition further claims the use of said components for the preparation of such a composition as well as its use as an agent for the prevention of adhesions.

Abstract: The invention concerns an intravaginal device comprising a combination of 17.beta.-estradiol and a supporting matrix for treating hypoestrogenic women. The device releases continously 17.beta.-estradiol at a rate of about 0.5 to about 25 .mu.g/24 h. The invention also comprises a method of preparing the device and a method of treating hypoestrogenic women by using the device.