Patents Assigned to Kabigen AB
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Patent number: 5455227Abstract: A lipoprotein possessing pulmonary surfactant activity comprising an alveolar polypeptide or protein and, covalently bound thereto, one or two fatty acid residue(s);a pharmaceutical composition comprising such lipoprotein and a phospholipid type of material; anda method of facilitating respiration in mammals including man, comprising administering an effective amount of such a lipoprotein or pharmaceutical composition to the respiratory tract of a patient subject to respiratory disorder so as to reduce surface tension at the air-liquid interface of the patient's alveoli.Type: GrantFiled: May 21, 1993Date of Patent: October 3, 1995Assignee: KabiGen ABInventors: Tore Curstedt, Hans Jornvall, Bjorn Lowenadler, Bengt Robertsson
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Patent number: 5223481Abstract: A lipoprotein possessing pulmonary surfactant activity comprising an alveolar polypeptide or protein and, covalently bound thereto, one or two fatty acid residue(s);a pharmaceutical composition comprising such lipoprotein and a phospholipid type of material; anda method of facilitating respiration in mammals including man, comprising administering an effective amount of such a lipoprotein or pharmaceutical composition to the respiratory tract of a patient subject to respiratory disorder so as to reduce surface tension at the air-liquid interface of the patient's alveoli.Type: GrantFiled: October 18, 1989Date of Patent: June 29, 1993Assignee: KabiGen ABInventors: Tore Curstedt, Hans Jornvall, Bjorn Lowenadler, Bengt Robertsson
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Patent number: 5202121Abstract: A thrombolytically active composition comprising in combination a modified tissue-type plasminogen activator (t-PA) as a major component and a normal human t-PA, Streptokinase or human urokinase as a minor component in a pharmaceutically acceptable excipient;a method of treating a thrombotic disorder; anda medicinal kit or package for use in treating thrombotic disorders.Type: GrantFiled: December 29, 1989Date of Patent: April 13, 1993Assignee: Kabigen ABInventors: Gunnar Pohl, Christer Mattsson
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Patent number: 5156959Abstract: A process for expressing proteins in Gram(-) bacteria and providing for extracellular secretion thereof, comprising the steps: a) introducing into a Gram(-) bacterium a recombinant DNA construction comprising a promoter, a signal sequence enabling translocation and processing, and a structural gene encoding the desired protein to be expressed; b) cultivating the bacterium under conditions resulting in filamentous growth; and c) recovering the extracellularly secreted protein; a recombinant DNA construction comprising:a promoter, a signal sequence and a structural gene including a cleavage region,wherein the structural gene is of the formula:(E).sub.n (B).sub.m -Y,where n is an integer .gtoreq.Type: GrantFiled: October 24, 1990Date of Patent: October 20, 1992Assignee: KabiGen ABInventors: Lars Abrahmsen, Tomas Moks, Bjorn Nilsson, Mathias Uhlen
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Construction of an IgG binding protein to facilitate downstream processing using protein engineering
Patent number: 5143844Abstract: A recombinant DNA fragment (Z) coding for an immunoglobulin G binding domain related to staphylococcal protein A. The methionine codon of the recombinant DNA fragment has been replaced with a codon of an amino acid residue other than methionine to enable expression of a methionine-free protein. The present invention is also directed to recombinant DNA sequence containing such recombinant DNAS fragment (Z) as well as a recombinant DNA molecule, plasmid vector and bacterial cell containing such recombinant DNAS fragment. Also disclosed is a process for cleaving a fused protein expressed in a biological system using said recombinant DNA fragment.Type: GrantFiled: October 9, 1990Date of Patent: September 1, 1992Assignee: KabiGen ABInventors: Lars Abrahmsen, Tomas Moks, Bjorn Nilsson, Mathias Uhlen -
Patent number: 5096886Abstract: A polypeptide having bactericidal activity, particularly against gram-negative bacteria, has been isolated from pig intestine. The porcine cecropin has the amino acid sequence: H.sub.2 N-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-AlaLys-Lys-Arg-Ile-S er-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-COOh. Pharmaceutical compositions containing such poypeptides, or functional derivatives thereof, are useful in therapeutic and prophylactic methods for inhibiting bacterial growth.Type: GrantFiled: May 31, 1990Date of Patent: March 17, 1992Assignees: Kabigen AB, Skandigen ABInventors: Hans G. Boman, Hans Jornvall, Jong-Youn Lee, Viktor Mutt
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Patent number: 4840785Abstract: A mammal intestinal hormone precursor having the following peptide structure: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-L-M-Ala-Arg-Leu-Gl n -Arg-Leu-Leu-Gln-Gly-Leu-Val-Gly-N-O, wherein L is Glu or Asp, M is Gly or Ser, and N and O are selected from Lys and Arg; compositions containing such precursor and a method of stimulating pancreatic secretion.Type: GrantFiled: November 10, 1986Date of Patent: June 20, 1989Assignee: Kabigen ABInventors: Guro Gafvelin, Mats Carlquist, Viktor Mutt
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Patent number: 4806336Abstract: A human intestinal hormone having the following peptide structure: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Le u-Gln-Arg-Leu-Gln-Gly-Leu-Val-NH.sub. 2 ; compositions containing such hormone; and a method of stimulating pancreatic secretion.Type: GrantFiled: November 7, 1986Date of Patent: February 21, 1989Assignee: KabiGen AB and Skandigen ABInventors: Mats Carlquist, Hans Jornvall, Wolf-Georg Forssmann, Lars Thulin, Catja Johansson, Viktor Mutt
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Patent number: 4520016Abstract: A non-lysozyme highly active bacteriolytic protein which is heat stable and has a relatively low molecular weight. The protein may be produced by immunizing an insect against E. coli and recovering the protein from the insect. The protein is useful for extracting proteins from genetically engineered bacteria and as a pharmaceutical for inhibiting certain bacteria.Type: GrantFiled: August 2, 1982Date of Patent: May 28, 1985Assignee: KabiGen ABInventors: Dan Hultmark, Hakan Steiner, Torgny Rasmuson, Hans G. Boman
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Patent number: 4355104Abstract: A non-lysozyme highly active bacteriolytic protein which is heat stable and has a relatively low molecular weight. The protein may be produced by immunizing an insect against E. coli and recovering the protein from the insect. The protein is useful for extracting proteins from genetically engineered bacteria and as a pharmaceutical.Type: GrantFiled: June 17, 1980Date of Patent: October 19, 1982Assignee: Kabigen ABInventors: Dan Hultmark, Hakan Steiner, Torgny Rasmuson, Hans G. Boman