Abstract: In an oil-free multistage gas compressor comprising cylinders, a plurality of compression pistons in respective cylinders and a transmission mechanism for reciprocating said compression pistons through guide pistons serially connected to said compression pistons, the improvement wherein a common space where these pistons come in and out is defined adjacent the connections, and a diaphragm is disposed in said space transversely whereby said compression pistons are oil-tightly separated from said guide pistons.