Patents Assigned to Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
  • Patent number: 5534547
    Abstract: The present invention provides novel prostaglandins D, that is, 13,14-dihydro-15-keto-PGDs, whieh have an excellent sedative and sleep-inducing activity, and so they are useful for tranquilizer and/or soporifics.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: July 9, 1996
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
  • Patent number: 5468880
    Abstract: Improvement in the technique of synthesizing prostaglandins, particularly those having at least one halogen atom at the 16- or 17-position, which comprises introducing a .omega. chain into the aldehyde thereby to enable considerable yield improvement in the production of .alpha.,.beta.-unsaturated ketones, and which does not involve hydrogen generation and can insure safe operation.A method of producing .alpha.,.beta.-unsaturated ketones by reacting aldehyde with 2-oxoalkyl phosphonate, wherein the reaction was carried out under the presence of a base and a zinc compound.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: November 21, 1995
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuji Ueno, Tomio Oda
  • Patent number: 5362751
    Abstract: The present invention provides a tracheobronchodilator comprising 15-keto-PGEs, reduced in stimuli against bronchi and other side effects.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: November 8, 1994
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
  • Patent number: 5317032
    Abstract: The present invention relates to cathartics comprising 15-keto-16-halogen-PGs as an essential ingredient without substantive side-effects; the catharic effect is thought mainly caused by an enteropooling effect.
    Type: Grant
    Filed: December 30, 1992
    Date of Patent: May 31, 1994
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Sachiko Kuno, Tomio Oda
  • Patent number: 5290811
    Abstract: A method of treatment for improving encephalic function which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective for improvement of encephalic function.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: March 1, 1994
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuji Ueno, Hiroyoshi Osama, Tomio Oda
  • Patent number: 5284858
    Abstract: The novel 13, 14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-ketoprostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E.Therefore, the novel 13, 14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: February 8, 1994
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
  • Patent number: 5011984
    Abstract: The present invention provides a production of 2-hydroxynaphthalene-6-carboxylic acid improved in the yield and the selective ratio, in which .beta.-naphthol and water formed in the reaction system are eliminated therefrom through the reaction.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: April 30, 1991
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Yoshiyasu Masada, Toru Mori
  • Patent number: 4994584
    Abstract: The present invention provides new compound, 10-substituted-5,9-dioxatricyclo[6.4.0.0.sup.2,6 ]dodecane-4-one, which is very useful as an intermediate for prostaglandin synthesis.
    Type: Grant
    Filed: January 19, 1990
    Date of Patent: February 19, 1991
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
  • Patent number: 4992295
    Abstract: The present invention provides a method of frozen surimi, surimi based products and additives for dehydrated minced fish meat, in which reduced hydrolyzed starch is mixed with fish meat and the mixture frozen, and whereby said starch prevents the frozen surimi from freezing denaturation.
    Type: Grant
    Filed: March 16, 1989
    Date of Patent: February 12, 1991
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Toshitaka Nakashima, Kunihiko Tomiyasu, Yatsuka Fujita
  • Patent number: 4966992
    Abstract: The present invention provides a method of production of aromatic hydroxycarboxylic acids by the reaction of alkaline metal salts of phenols or naphthols with carbon dioxide, in which free phenols or free naphthols produced as by-products in the reaction system are removed from the system so as to control the content of free phenols or free naphthols at a suitable level, by which a purer objective compound can be obtained at high yield under the condition of lower temperature and shorter time.
    Type: Grant
    Filed: January 18, 1989
    Date of Patent: October 30, 1990
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Yoshiyasu Masada, Yoshihiko Kuwae, Keiji Kawata
  • Patent number: 4954358
    Abstract: The present invention provides a new inhibitor for Bacillus cereus which has been designated officially as a pathogen of food poisoning, which comprises a protamine or its salt as an essential component.
    Type: Grant
    Filed: December 3, 1987
    Date of Patent: September 4, 1990
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Yatsuka Fujita, Munemitsu Yamamoto, Hiroshi Kozakai
  • Patent number: 4918202
    Abstract: The present invention provides new compound, 10-substituted-5,9-dioxatricyclo[6.4.0.0.sup.2,6 ]dodecane-4-one, which is very useful as an intermediate for prostaglandin synthesis.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: April 17, 1990
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
  • Patent number: 4910039
    Abstract: The present invention provides an additive for frozen surimi containing branched dextrins and a surface active agent for food; the frozen surimi into which the additives for surimi of the present invention are added does not give off a fish smell or a bad smell after thawed, and the fish meat product such as kamaboko, chikuwa and the like which is produced from the frozen surimi has a bad smell.
    Type: Grant
    Filed: April 19, 1988
    Date of Patent: March 20, 1990
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Yatsuka Fujita, Kunihiko Tomiyasu, Toshitaka Nakashima
  • Patent number: 4894359
    Abstract: The present invention provides a novel bis(phenoxymethyl)benzene derivative or bis(naphthoxymethyl)benzene derivative, which improves the stability of image on a heat sensitive recording paper composed of a leuco dye and a developer.
    Type: Grant
    Filed: May 31, 1988
    Date of Patent: January 16, 1990
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Shinichi Katsura, Yoshirou Uchiyama, Satomi Inoue
  • Patent number: 4855482
    Abstract: The present invention provides a novel bis(phenoxymethyl)benzene derivative or bis(naphthoxymethyl)benzene derivative, which improves the stability of image on a heat sensitive recording paper composed of a leuco dye and a developer.
    Type: Grant
    Filed: June 26, 1987
    Date of Patent: August 8, 1989
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Shinichi Katsura, Yoshirou Uchiyama, Satomi Inoue
  • Patent number: 4840941
    Abstract: Method of treatment of diseases caused by retroviruses which comprises administering therapeutically effective amount of a natural or synthetic oligo- or polysaccharide having at least one S-oxoacid group attached to the saccharic carbon atom through a linking group of lower molecular weight or a pharmaceutically acceptable salt thereof to a subject in need of such treatment.
    Type: Grant
    Filed: January 15, 1988
    Date of Patent: June 20, 1989
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Ryuji Ueno, Sachiko Kuno, Akihiko Tabata
  • Patent number: 4804415
    Abstract: A process for producing an azo pigment, which comprises coupling an aromatic diazonium compound with 3-hydroxy-2-naphthoic acid and at least one binaphthol and optionally, laking the resulting pigment.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: February 14, 1989
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Shigeru Ito, Shin Fujimoto, Mayumi Iwao
  • Patent number: 4774237
    Abstract: The present invention provides expellants of phytopothogenic microbes comprising rifamycins, which have excellent in prevention of disease in plants with little adverse influence to human body and environments.
    Type: Grant
    Filed: February 6, 1987
    Date of Patent: September 27, 1988
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Hiroshi Kita, Tadashi Nakagawa
  • Patent number: 4746721
    Abstract: A melt-processable copolyester composed of the following structural units (I), (II) and (III) and/or (IV) as main structural components, whereinunit (I) is represented by the formula ##STR1## wherein X.sub.1, X.sub.2, X.sub.3 and X.sub.4, independently from each other, represent H, F, Cl, Br, CH.sub.3 or C(CH.sub.3).sub.3, provided that X.sub.1 to X.sub.4 do not simultaneously represent H, and n is 2 or 4,unit (II) is at least one unit selected from the group consisting of ##STR2## wherein at least one of the hydrogen atoms in each aromatic ring in units (II), (III) and (IV) may be substituted by an alkyl or alkoxy group having 1 to 4 carbon atoms or a halogen atom.The proportion of unit (I) is 2.5 to 35 mole %, the proportion of unit (II) is 2.5 to 35 mole %, and the proportion of unit (III), (IV) or a combination of units (III) and (IV) is 30 to 95 mole %.
    Type: Grant
    Filed: August 5, 1986
    Date of Patent: May 24, 1988
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Yoshiyasu Masada, Taihei Hamasaki, Toru Mori
  • Patent number: 4684712
    Abstract: Wholly aromatic polyesters having improved mechanical properties are produced by polycondensing a raw material or raw material mixture capable of forming an aromatic polyester and not more than about 18 mole %, based on the total amount of the entire raw materials, of 2-hydroxynaphthalene-6-carboxylic acid or its derivative.
    Type: Grant
    Filed: June 6, 1986
    Date of Patent: August 4, 1987
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Kazuyuki Sakota, Yasunori Nakamura