Abstract: An implant is produced by coating a core material with a calcium phosphate type compound and converting the coating layer into an apatite type ceramic layer by a hydrothermal treatment.

Abstract: A salt-excretion promoting composition, characterized by containing (i) 10 parts by weight of agar and (ii) 1 to 15 parts by weight of at least one polysaccharide selected from the group consisting of sodium alginate, .lambda.- and .kappa.-carrageenan and xanthane gum.

Abstract: A simple blood sampling device composed of a vacuum chamber, a skin suction portion and a piercing and cutting means.

Abstract: A device for detecting an R-wave in an electrocardiogram, comprising a filter for passing a frequency band including the R-wave and a peak hold circuit for forming R-wave pulse signals from signals passed through the filter by holding the peak phase of the R-wave. According to the device for detecting an R-wave in an electrocardiogram, the R-wave in an electrocardiogram can be effectively discriminated from noise, and also an R-wave deformed by arrhythmia can be stably detected.

Abstract: A transcutaneously implantable element in which at least a portion thereof in contact with the cutaneous tissue of a living body is composed of a ceramic material comprising, as the main raw material, at least one member selected from the group consisting of hydroxyapatite, tricalcium phosphate, and tetracalcium phosphate, and which comprises (a) an electrically conductive member for electrically connecting the interior and exterior of the living body to each other or (b) a through hole for mechanically connecting the interior and exterior of the living body to each other.This transcutaneously element can be semipermanently and safely used in a living body without causing any undesirable bacterial infection, bleeding, and background noise.

Abstract: A transcutaneously implantable element in which at least a portion thereof in contact with the cutaneous tissue of a living body is composed of a ceramic material comprising, as the main raw material, at least one member selected from the group consisting of hydroxyapatite, tricalcium phosphate, and tetracalcium phosphate, and which comprises (a) an electrically conductive member for electrically connecting the interior and exterior of the living body to each other or (b) a through hole for mechanically connecting the interior and exterior of the living body to each other.This transcutaneously element can be semipermanently and safely used in a living body without causing any desirable bacterial infection, bleeding, and background noise.

Abstract: An anticariogenic or antiperiodontitic agent containing, as an active component, adenosine or its derivatives having an antibacterial activity against Streptococcus mutans or Bacteroides gingivalis. This anticariogenic or antiperiodontitic agent has strong inhibitory effects on the growth of Streptococcus mutans causing dental caries and Bacteroides gingivalis causing periodontitis and has neither influence on intestinal microflora nor any side-effects when orally administered.

Abstract: A small-sized low frequency curing apparatus which can be applied directly to the object to be stimulated such as a body or the like.Generating high frequency boosted pulses by electrical energy from a small-sized power source, accumulating the boosted pulses temporarily until a predetermined amount at which stimulation is effective for the organism is reached, and then discharging the accumulated charges to generate low frequency pulses having an effective amplitude for the stimulation as an electrical stimulation. Thus, it is possible to apply a sufficient magnitude of and a stable electrical stimulation to an object to be stimulated regardless of the small capacity of the small-sized power source.

Abstract: A low frequency curing apparatus includes a power source; a boosted pulse generating unit for generating a train of boosted pulses in response to a first pulse signal; and accumulating unit for accumulating the boosted pulses to a predetermined amount; a low frequency pulse outputting unit for outputting the accumulated boosted pulses as low frequency pulses in response to a second pulse signal; a pair of electrode members able to be applied in a plane state to an object to be stimulated, for transmitting the low frequency pulses to the object; and a signal processing unit for outputting the first and second pulse signals based on a predetermined algorithm. A pulse width or a pulse interval of the first pulse signal or second pulse signal is changed, and as a result, a variety of low frequency stimulation effects can be applied to the object to be stimulated.

Abstract: A material for endermic administration pre-treatment is disclosed wherein the material comprises a support and a substance capable of removing corneum, for example, an adhesive, and the substance is substantially uniformly distributed on the support in the form of small areas discontinuous to each other at a density of 0.001 to 5%. Pre-treatment of the skin by this material enhances the absorption of a medicament in an endermic administration.

Abstract: An improved process for the manufacture of a metal oxide is disclosed. In the process wherein a hydrolyzable organometallic compound is hydrolyzed by an alkaline hydrolyzing agent in an alkaline organic solvent, and thereafter, the metal oxide is formed by a condensation reaction of a metal hydroxide resulting from the hydrolysis of the organometallic compound, the improvement comprises feeding the organometallic compound and the hydrolyzing agent into the organic solvent so that a concentration of the hydrolyzed compound is initially above a critical level of supersaturation, and thereafter, is maintained in a range from above an upper limit of solubility to the critical level of super-saturation. According to the above process, the metal oxide can be obtained in the form of a powder material with a uniform particle size distribution.

Abstract: A signal processing system capable of converting various input analog signals including bioelectric signals, such as electrocardiographic signals, electro-encephlographic signals, and pulse wave signals, into digital signals by A/D converter, compressing the converted data by data compression, recording the compressed data on a compressed data recorder, regenerating the compressed data fetched from the compressed data recorder by data regeneration including a Huffman decoder, mode selector and regenerated data forming device, and then providing analog signals corresponding to the regenerated data.

Abstract: Hypocholesterolemically and/or hypotriglyceridemically active RNA fractions having the following characteristics:(a) Molecular weight by gel filtration: 2,000.+-.1,000(b) Base composition ratio of nucleic acid: uracil: guanine: cytosine: adenine=13.0: 16.0: 16.0: 10.0(c) Infrared absorption sepctrum: shown in FIG. 2(d) Physiological characteristics: having a hypocholesterolemic and/or hypotriglyceridemic activity in mammals.These hypocholesterolemically and/or hypotriglyceridemically active RNA fractions can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypocholesterolemically and/or hypotriglyceridemically active RNA fractions from the cultured cells of the microorganism.

Abstract: Hypocholesterolemically active RNA fractions having the following characteristics:(a) Molecular weight by gel filtration: 11,000.+-.9,000(b) Base composition ratio of nucleic acid: uracil:guanine:cytosine:adenine=1:1:2:1(c) Infrared absorption spectrum: shown in FIG. 2(d) Physiological characteristics: having a hypocholesterolemic activity in mammals.These hypocholesterolemically active RNA fractions can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypocholesterolemically active RNA fractions from the cultured cells of the microorganism. These hypocholesterolemically active RNA fractions can be used as an active ingredient of a hypocholesterolemic or antiatherosclerotic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypocholesterolemic or antiatherosclerotic pharmaceutical compositions, which is suitable for oral administration to mammals.

Abstract: A hypocholesterolemically active protein capable of reducing the blood cholesterol in mammals having the following characteristics:(a) Molecular weight by gel filtration: 30,000.+-.7,000(b) Isoelectric point: 7.9.+-.0.2(c) Amino acid composition (mole %):______________________________________ Glycine 25.23 Alanine 10.98 Glutamate 10.34 Asparaginate 8.20 Lysine 6.39 Leucine 5.58 Valine 5.41 Isoleucine 5.18 Threonine 4.23 Tyrosine 4.19 Serine 3.46 Proline 2.62 Arginine 2.60 Phenylalanine 2.51 Methionine 1.56 Histidine 1.30 Cysteine 0.16 ______________________________________(d) Pattern of electrophoresis: a sharp band on the anode side on polyacrylamide gel electrophoresis. This hypocholesterolemically active protein is derived from a microorganism belonging to the genus Streptococcus.

Abstract: A bacterial cell product orally administered to lower serum cholesterol and/or triglyceride level in mammals obtained by cultivating a microorganism belonging to the genus Streptococcus and having a N-acetyl-.beta.-D-glucosaminidase activity in an adequate culture medium therefor, and collecting the cultivated microorganism from the resultant culture.

Abstract: An apparatus for detecting a high frequency artifact contained in an electrocardiogram signal is disclosed, which enables the presence of the high frequency artifact to be detected with a high precision by extracting high frequency components having a frequency and amplitude equal to or more than a predetermined value within a predetermined time interval of the input electrocardiogram signal by converting the high frequency components to pulses, by counting the pulses, and by comparing the counted pulses with the predetermined value. This apparatus is used in connection with, for example, an electrocardiograph, an electrocardiogram analyzer, and the like, and enables precise discrimination between an abnormal electrocardiogram waveform and the high frequency artifact.

Abstract: The present invention relates to a method for killing cells characterized by bringing a material containing living cells into contact with a non-conductor-carrying photosemiconductor material or a cytocidal material containing the photo semiconductor material and killing the living cells by irradiating light onto the non-conductor-carrying photosemiconductor material, and to a cytocidal agent comprising non-conductor-carrying photosemiconductor material. This non-conductor-carrying photosemiconductor material is relatively inexpensive, since it does not carry a conductor and may be used safely for sterilizing drinking water, food, the human body, and the like because it does not release any poisonous metal ions derived from the conductor in use.

Abstract: A device for iontophoresis including an electric source, a pulse generator, a working electrode, and a counter electrode is described. This device has a circuit for discharging the charges accumulated in said electrodes during each intermission period of therapeutic pulses generated by said pulse generator (i.e., a circuit for effecting the depolarization between the above-mentioned both electrodes during each intermission period of therapeutic pulses).This device can be directly and very easily applied to the human skin, without causing undesirable irritation in the skin, especially without causing burns and rubefaction in the skin.

Abstract: An anticariogenic or antiperiodontitic agent containing, as an active component, the bacterial cells and/or water-soluble extracts of a microorganism belonging to the genus Streptococcus or the genus Lactobacillus having antibacterial activity against Streptococcus mutans or the genus Bacteriodes.This anticariogenic or antiperiodontitic agent has strong inhibitory effects on the growth of Streptococcus mutans causing dental caries and Bacteroides causing periodontitis and has no influence on intestinal microflora when orally administered.