Abstract: [Problem] The purpose of the present invention is to provide a pharmaceutical composition containing an antibacterial agent, which is effective in elucidating one cause of dementia, and in treatment thereof. [Solution] The present invention provides a pharmaceutical composition for treatment of dementia, containing an antibacterial agent. The present invention moreover provides a pharmaceutical composition for treatment of extreme halophile infections, containing a folic acid synthesis inhibitor.

Abstract: The present invention aims to provide a compound capable of inhibiting PCA-1 that can be a target for a novel treatment method of various diseases, and pharmaceutical use of the compound. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof.

Abstract: A parallel-type AD converter includes: a plurality of comparators that receive comparison reference potentials different from one another and compare the comparison reference potentials and received analog input signals; an encoder that encodes outputs of the plurality of comparators to output digital signals; and a resistor ladder circuit that resistance-divides a reference voltage to generate the comparison reference potentials and supplies the comparison reference potentials to the comparators through output nodes each positioned between resistors, and is designed to supply a correction current corresponding to noise currents that the comparators generate to the output nodes of the comparison reference potentials in the resistor ladder circuit, and thereby the noise currents that the comparators generate are offset by the correction current, a bias current in the resistor ladder circuit can be decreased, and accuracy deterioration in AD conversion can be suppressed.

Abstract: An observation and photography apparatus that has a polishing mechanism attached thereto. The polishing mechanism is provided with a turntable with a perpendicular rotation shaft, a polishing cloth for polishing the surface of a sample attached to the bottom surface of the turntable, and a polishing-fluid spraying nozzle disposed below the polishing cloth for spraying polishing fluid containing polishing material upward to we the polishing cloth.

Abstract: A parallel-type AD converter includes: a plurality of comparators that receive comparison reference potentials different from one another and compare the comparison reference potentials and received analog input signals; an encoder that encodes outputs of the plurality of comparators to output digital signals; and a resistor ladder circuit that resistance-divides a reference voltage to generate the comparison reference potentials and supplies the comparison reference potentials to the comparators through output nodes each positioned between resistors, and is designed to supply a correction current corresponding to noise currents that the comparators generate to the output nodes of the comparison reference potentials in the resistor ladder circuit, and thereby the noise currents that the comparators generate are offset by the correction current, a bias current in the resistor ladder circuit can be decreased, and accuracy deterioration in AD conversion can be suppressed.

Abstract: Electrons are introduced to a cathode (1) side of a cell (10) to promote the reduction of carbon dioxide. On the other hand, the oxidation of methane is promoted in an anode (2) side by an oxide ion transported via a porous GDC electrolyte (3). When carbon monoxide and an oxide ion are generated, they are transported to the anode (2) together with methane gas to generate carbon monoxide and hydrogen. In addition, Cu and an oxide ion are reacted in the anode (2) to promote the oxidation of methane gas.

Abstract: A circuit element is arranged on an organic substrate and connected to a wiring pattern arranged on the organic substrate. An internal connection electrode is formed on a conductive support body by electroforming so as to obtain a unitary block of the internal connection electrode and the support body. Each end of each of the internal connection electrodes connected into a unitary block by the support body is connected to the wiring pattern. After the circuit element is sealed by resin, the support body is peeled off, so as to obtain individual internal connection electrodes separately and the other end of each of the internal connection electrodes is used as an external connection electrode on the front surface while the external connection electrode on the rear surface is connected to the wiring pattern.

Abstract: A heatsink is provided with a base body opposed to a heat generating body and absorbing heat from the heat generating body. Thermal resistance of that opposed portion of the base body which is opposed to the heat generating body is higher than thermal resistance of a surrounding portion surrounding the opposed portion.

Abstract: This invention provides a method for efficiently detecting DNA methylation. The method for detecting DNA methylation comprises subjecting DNA to bisulfite treatment, subjecting DNA after bisulfite treatment to a first PCR, subjecting the resultant to nested PCR, and subjecting amplified DNA to denaturing gradient gel electrophoresis.

Abstract: This invention provides a peptide that comprises an amino acid sequence consisting of 14 to 18 amino acid residues represented by Formula (I) and is capable of binding to human IgA: (SEQ?ID?NO:?1) H-(X1)-V-C-L-S-Y-R-(X2)-(X3)-G-(X4)-P-(X5)-C- (X6)-(X7)-(X8)(I) wherein each X is independently selected from among the following: X1 represents a Gln residue or a Met residue; X2 and X3 each independently represent an arbitrary amino acid residue other than Cys or either or both thereof are deleted; X4 represents an Arg residue or a Gln residue; X5 represents a Val residue or a Thr residue; X6 represents a Phe residue or a Tyr residue; X7 represents a Ser residue or is null; and X8 represents a Leu residue, a Thr residue, or is null, provided that, when X1 represents a Met residue, X7 represents a Ser residue or is null, and X8 is null. The invention also provides a method for purifying or analyzing human IgA using such peptide.

Abstract: The present invention provides means and a method assuring the effectiveness of early diagnosis of cancers including gastric cancers. Specifically, the present invention provides an antibody, which is prepared using, as an antigen, (a) a peptide comprising at least contiguous amino acids at positions 69 to 75 in the amino acid sequence of SEQ ID NO: 2, or (b) a peptide consisting of an amino acid sequence in which one or several amino acids are deleted, substituted or added in at least contiguous amino acids at positions 69 to 75 in the amino acid sequence of SEQ ID NO: 2, and having the antigenicity of human MUC1 protein, and which is reactive with human mucin 1 (MUC1) protein.

Abstract: As a result of collecting blood from pancreatic cancer patients, esophageal cancer patients, and stomach cancer patients, and conducting mass spectrometry on N-linked sugar chains in the plasmas, sugar chains whose abundances are significantly different from those of healthy subjects have been successfully identified from the blood samples of the cancer patients.

Abstract: A control method is proposed that controls inter-component phase difference solitons by using splitting or fusion caused by the interaction between inter-component phase difference solitons themselves, without the need for application of external energy.

Abstract: A polyion complex (PIC) or a PIC nanoparticle that may be easily prepared, and that is finally disappeared in vivo due to its suitable biodegradability while exhibiting high stability in vivo, an immunotherapy agent comprising the PIC nanoparticle to which various antigen proteins or peptides may be easily conjugated or incorporated and/or which may be easily mixed with the antigen proteins or peptides, as well as a process for preparing thereof are provided. Specifically, a polyion complex (PIC) comprising a hydrophobized poly(acidic amino acid) and a basic polypeptide, a nanoparticle thereof having a particle shape, an immunotherapy agent comprising the PIC nanoparticle, as well as a process for preparing the PIC, comprising steps of introducing a hydrophobic amino acid to a poly(acidic amino acid) to prepare a hydrophobized poly(acidic amino acid), and dissolving the hydrophobized poly(acidic amino acid) prepared to a buffer, and it is mixed with a basic polypeptide dissolved in a buffer.

Abstract: A novel ligand conjugate which is effectively utilizable for analyzing a function of a protein; a ligand-supporting object; and a method of analyzing a protein. The ligand conjugate has a structure which comprises: a linker compound having a structure represented by the following General Formula (1): (wherein n and p each is an integer of 0 to 6) in which X is a structure comprising one, two, or three hydrocarbon derivative chains which have an aromatic amino group at the end and may have a carbon-nitrogen bond in the main chain, Y is a hydro-carbon structure containing one or more sulfur atoms, and Z is a straight-chain structure comprising a carbon-carbon bond or carbon-oxygen bond; and a sugar which has a reducing end and is bonded to the linker compound through the aromatic amino group.

Abstract: A diagnostic marker for digestive organ cancer according to the present invention is used for determining whether or not to have a digestive organ cancer. The diagnostic marker for digestive organ cancer contains at least one of N-binding type sugar chains released from a glycoprotein contained in blood and represented by the following formulas (1) to (6). This makes it possible to provide a diagnostic marker for digestive organ cancer capable of being used for an inspection method of easily determining whether or not to have a digestive organ cancer at an early stage, and an inspection method for digestive organ cancer of easily determining whether or not to have a digestive organ cancer at an early stage.

Abstract: This invention provides a quantitative assay technique for soft agar colony formation that can be carried out rapidly with high accuracy. Specifically, this invention relates to a method for evaluation of cell survival comprising: a step of overlaying agar at the bottom of a vessel with agar containing cells, overlaying the agar containing cells with a medium and culturing the cells; a step of removing the medium, adding tetrazolium that produces water-soluble formazan and an electron carrier and culturing the cells; and a step of evaluating cell survival based on the color developed by the water-soluble formazan.

Abstract: An object of the present invention is to provide a cartilage/bone destruction suppressor which can suppress the destruction of cartilage or bone seen in rheumatoid arthritis, osteoarthritis, bone metastasis of malignant tumor, or the like. The present invention relates to a cartilage or bone destruction suppressor comprising an antibody against folate receptor ? or a complex of the antibody and a biologically or chemically active substance.

Abstract: A lighting apparatus is provided with: a light-emitting unit, a heat spreader in heat-conductive contact with the light-emitting unit that diffuses the heat conducted from the light-emitting unit, heat pipes with one end in heat-conductive contact with the heat spreader that transport heat to their other end, and a lower row of cooling fins and upper row of cooling fins that are in heat-conductive contact with the other ends of the heat pipes, and that radiate the heat conducted from the heat pipes into the environment.

Abstract: An object is to provide a novel therapeutic drug for adult T-cell leukemia having an ATL cell specific antitumor effect. The therapeutic drug for adult T-cell leukemia according to the invention is characterized by containing a compound represented by the formula I or a prodrug thereof, wherein R1 is H, OH, an alkoxy group, an acyl group, or a thioacyl group, R2 is an acyl group, a thioacyl group, CONR7R8, or CSNR7R8 (R7 and R8 being each independently H, an alkyl group containing 1 to 3 carbon atoms, or a phenyl group), or R1 and R2 together may form a ring, X1 and X2 may be the same or different and are each —CR3R4—, —SiR3R4— or oxygen, and R3 and R4 may be the same or different and are each an alkyl group containing 1 to 6 carbon atoms.