Abstract: The present invention relates to a method for producing luminescent nanoparticles wherein particle size of the nanoparticles is controlled. The method of the present invention includes admixing two or more rare earth metal salts in a first solvent and an organic oil to form a reaction mixture, and subjecting the reaction mixture to an inert gas so that flow rate of the inert gas is at least 2-5 L/h and pressure in the reaction vessel is at least 50 Pa over atmospheric pressure, preferably 50-80 Pa over atmospheric pressure.
Type:
Grant
Filed:
March 10, 2017
Date of Patent:
June 21, 2022
Assignee:
KAIVOGEN OY
Inventors:
Eeva Junkkari, Terhi Riuttamäki, Johanna Pyylampi, Jarkko Karvinen, Antti Pihlava
Abstract: The present disclosure relates to non-invasive diagnostics of cancers, such as breast cancer, colorectal cancer, pancreatic cancer and prostate cancer, on the basis of altered glycosylation patterns of cancer-associated biomarkers.
Type:
Application
Filed:
July 14, 2017
Publication date:
September 9, 2021
Applicant:
Kaivogen Oy
Inventors:
Kamlesh GIDWANI, Kim PETTERSSON, Henna KEKKI
Abstract: The present disclosure relates to methods and a kit for diagnosing, prognosing and/or monitoring a gynaecological disease, especially epithelial ovarian cancer, on the basis of altered glycosylation pattern of CA125. More specifically, said altered glycosylation pattern relates to that recognizable by MGL.
Abstract: The present disclosure relates to methods and a kit for diagnosing, prognosing and/or monitoring a gynaecological disease, especially epithelial ovarian cancer, on the basis of altered glycosylation pattern of CA125. More specifically, said altered glycosylation pattern relates to that recognizable by MGL.
Abstract: The present invention relates to a method for producing luminescent nanoparticles wherein particle size of the nanoparticles is controlled. The method of the present invention includes admixing two or more rare earth metal salts in a first solvent and an organic oil to form a reaction mixture, and subjecting the reaction mixture to an inert gas so that flow rate of the inert gas is at least 2-5 L/h and pressure in the reaction vessel is at least 50 Pa over atmospheric pressure, preferably 50-80 Pa over atmospheric pressure.
Type:
Application
Filed:
March 10, 2017
Publication date:
March 28, 2019
Applicant:
KAIVOGEN OY
Inventors:
Eeva JUNKKARI, Terhi RIUTTAMÄKI, Johanna PYYLAMPI, Jarkko KARVINEN, Antti PIHLAVA
Abstract: The invention relates to analysis of photon upconversion luminescent inorganic lanthanide-doped nanomaterials and/or separation and/or purification of them from other materials such as biomolecules and/or chemicals used e.g. for bioconjugation in preparation of reagents based on upconverting lanthanide nanoparticles for bioanalytical assays. The invention utilizes a high gradient magnetic separator (HGMS) and it can be applied from large submicron materials to small nanoparticles just nanometers or tens of nanometers in diameter. It is also scalable from small analytical scale to preparative scale.