Patents Assigned to Kake Educational Institution
  • Patent number: 12553055
    Abstract: An auxin-inducible degron system kit that controls degradation of a target protein in a non-plant-derived eukaryotic cell, the kit containing a first nucleic acid that encodes a mutant TIR1 family protein having a mutation at an auxin-binding site, an auxin analog that has an affinity to the mutant TIR1 family protein and a second nucleic acid that encodes a degradation tag containing at least a part of an Aux/IAA family protein and having an affinity to a complex of the mutant TIR1 family protein and the auxin analog.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: February 17, 2026
    Assignees: Inter-University Research Institute Corporation Research Organization of Information and Systems, KAKE EDUCATIONAL INSTITUTION
    Inventors: Masato Kanemaki, Ken-Ichiro Hayashi
  • Patent number: 12522836
    Abstract: A genetically modified non-human animal in which an auxin-inducible degron system controls degradation of a target protein in a living body includes: a chromosome containing a first nucleic acid that encodes a mutant TIR1 family protein having a mutation at an auxin-binding site and having affinity to an auxin analog.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: January 13, 2026
    Assignees: Inter-University Reseach Institute Corporation Research Organization of Informaton and Systems, KAKE EDUCATIONAL INSTITUTION
    Inventors: Masato Kanemaki, Ken-Ichiro Hayashi, Naomi Kitamoto, Yumiko Saga, Rieko Ajima
  • Patent number: 12357612
    Abstract: An object of the present invention is to provide a low molecular weight compound having a prophylactic or therapeutic action on cancer. A compound of the following formula (1), a compound of the following formula (2), or the like can be administered by a method such as oral administration to prevent or treat cancers such as colorectal cancer.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: July 15, 2025
    Assignees: TOHOKU UNIVERSITY, KAKE EDUCATIONAL INSTITUTION
    Inventors: Takaaki Abe, Shinobu Ohnuma, Michiaki Unno, Kenichiro Hayashi
  • Publication number: 20250144614
    Abstract: To provide an anion exchange resin which has an anion exchange group having high alkali resistance and in which a main chain structure is not affected even if the anion exchange group decomposes. The anion exchange resin according to the present invention is characterized by having an imidazolium group as an anion exchange group in a side chain.
    Type: Application
    Filed: March 28, 2023
    Publication date: May 8, 2025
    Applicants: KAKE EDUCATIONAL INSTITUTION, TOKUYAMA CORPORATION
    Inventors: Hideyuki HIGASHIMURA, Md Chanmiya SHEIKH, Takenori ISOMURA, Masahiro UWAMORI
  • Publication number: 20250122250
    Abstract: An auxin-degron system kit controlling degradation of a target protein in a non-plant-derived eukaryotic cell, in which the auxin-degron system kit includes a first nucleic acid encoding a mutant TIR1 family protein that has a mutation at an auxin-binding site; an auxin analog having an affinity for the mutant TIR1 family protein; and a second nucleic acid encoding a degradation tag that includes at least a partial Aux/IAA family protein and has an affinity for a complex of the mutant TIR1 family protein and the auxin analog.
    Type: Application
    Filed: August 5, 2022
    Publication date: April 17, 2025
    Applicants: Inter-University Research Institute Corporation Research Organization of Information and Systems, Kake Educational Institution
    Inventors: Masato Kanemaki, Ken-ichiro Hayashi, Takefumi Negishi
  • Patent number: 12230976
    Abstract: [PROBLEM] To provide a magnetic resonance wireless power transfer device which allows constant transmission power and high transmission efficiency to be maintained over a long transmission distance even when the distance (transmission distance) between a transmitter coil and a receiver coil changes.
    Type: Grant
    Filed: February 4, 2022
    Date of Patent: February 18, 2025
    Assignees: KAKE EDUCATIONAL INSTITUTION, ADTEX INC.
    Inventor: Hiroki Ishida
  • Patent number: 12139459
    Abstract: An object of the present invention is to provide an agent for enhancing fertilization function of a mammal sperm, which comprises a low molecular compound which can be produced relatively easily and inexpensively as an active ingredient, and a method for enhancing fertilization function of a mammal sperm and a method for preparing a mammal fertilized egg, which use a low molecular compound which can be produced relatively easily and inexpensively. An agent comprising one or more compounds selected from the group consisting of compounds of the following formula (I0), formula (II), and formula (III), and physiologically acceptable salts thereof when R3 is OH is used as an agent for enhancing fertilization function of a mammal sperm.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: November 12, 2024
    Assignees: TOHOKU UNIVERSITY, KAKE EDUCATIONAL INSTITUTION
    Inventors: Takaaki Abe, Nobuo Yaegashi, Masahito Tachibana, Kenichiro Hayashi
  • Patent number: 11969334
    Abstract: An artificial blood vessel 10 comprises: an artificial blood vessel body 12; and a carbon material film 11 that covers the inner wall of the artificial blood vessel body 12. The inner wall which is covered by the carbon material film 11 is configured so that the water vapor adsorption isotherm shows desorption hysteresis.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: April 30, 2024
    Assignee: KAKE EDUCATIONAL INSTITUTION
    Inventors: Yasuhiro Fujii, Susumu Ozawa, Tatsuyuki Nakatani, Yuichi Imai
  • Publication number: 20230257686
    Abstract: The present invention is to provide a method for producing a cartilage tissue which comprises a step of providing a substrate for producing cell aggregates provided with a plurality of spots comprising a copolymer containing recurring units derived from monomers represented by the following formulae (I) and (II): [wherein Ua1, Ua, Ra1, Ra2 and Rb are as described in the specification and claims] on a substrate having an ability to suppress adhesion of cells; a step of seeding human cartilage progenitor cells which are positive for PRRX1 protein and derived from pluripotent stem cells on the substrate; a step of producing cell aggregates by culturing the cells; and a step of culturing the aggregates to produce a cartilage tissue.
    Type: Application
    Filed: July 1, 2021
    Publication date: August 17, 2023
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, KAKE EDUCATIONAL INSTITUTION, NISSAN CHEMICAL CORPORATION
    Inventors: Takeshi TAKARADA, Ryosuke IWAI, Kohei SUZUKI, Natsuki FUKASAWA
  • Publication number: 20230116517
    Abstract: A substrate for producing cell aggregates provided with a plurality of spots which comprises a polymer containing a recurring unit derived from a monomer represented by the following formula (I): wherein Ua1, Ua2, Ra1 and Ra2 are as defined herein, on a substrate having an ability to inhibit adhesion of cells, wherein a ratio of a total area of the spots to a surface area of the substrate is 30% or more, a diameter of each spot is 50 to 5,000 ?m, and a distance between the spots is 30 to 1,000 ?m, a method for producing the same, and a method for producing cell aggregates using such a substrate and a method of improving cell utilization efficiency at the time of producing the cell aggregates.
    Type: Application
    Filed: February 19, 2021
    Publication date: April 13, 2023
    Applicants: NISSAN CHEMICAL CORPORATION, KAKE EDUCATIONAL INSTITUTION
    Inventors: Kohei SUZUKI, Yoshiomi HIROI, Ryosuke IWAI
  • Patent number: 11147796
    Abstract: It is to provide an agent for preventing or improving hearing loss, which comprises a low molecular compound which can be produced relatively easily and inexpensively as an active ingredient. One or more compounds selected from the group consisting of compounds represented by the following formulas (I0), (II), and (III) and a pharmaceutically acceptable salt of the compounds when R3 is OH are used as an agent for preventing or improving hearing loss.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: October 19, 2021
    Assignees: TOHOKU UNIVERSITY, KAKE EDUCATIONAL INSTITUTION
    Inventors: Takaaki Abe, Yukio Katori, Yohei Honkura, Fumika Nanto, Kenichiro Hayashi
  • Patent number: 10830723
    Abstract: A gas sensor containing counter electrodes and a semiconductor nanowire 4 disposed between the counter electrodes 2, 3, wherein the semiconductor nanowire 4 is in a state where light can be irradiated, which sensor measures changes in the electric current associated with adsorption of a gas to the semiconductor nanowire 4, wherein the electric current is generated by irradiation of light on the semiconductor nanowire with a voltage applied to the counter electrodes 2, 3.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: November 10, 2020
    Assignee: KAKE EDUCATIONAL INSTITUTION
    Inventor: Norio Akiyama
  • Patent number: 9759676
    Abstract: A gas sensor array containing a gas flow path in which a gas to be analyzed flows, and a plurality of gas sensors set along the gas flowing direction of the gas flow path, wherein the gas sensors each has a constitution wherein semiconductor microcrystals that come into contact with the gas to be analyzed that flows in the above gas flow path are disposed between two electrodes.
    Type: Grant
    Filed: September 2, 2013
    Date of Patent: September 12, 2017
    Assignee: Kake Educational Institution
    Inventor: Norio Akiyama
  • Publication number: 20170138879
    Abstract: A gas sensor containing counter electrodes and a semiconductor nanowire 4 disposed between the counter electrodes 2, 3, wherein the semiconductor nanowire 4 is in a state where light can be irradiated, which sensor measures changes in the electric current associated with adsorption of a gas to the semiconductor nanowire 4, wherein the electric current is generated by irradiation of light on the semiconductor nanowire with a voltage applied to the counter electrodes 2, 3.
    Type: Application
    Filed: July 3, 2015
    Publication date: May 18, 2017
    Applicant: KAKE EDUCATIONAL INSTITUTION
    Inventor: Norio AKIYAMA
  • Patent number: 9134265
    Abstract: The invention provides a gas sensitive material made from microcrystalline selenium (preferably selenium nanowire) and a gas sensor having an element structure wherein the gas sensitive material is disposed between two electrodes. The invention allows for the kind of organic gas to be distinguished, because microcrystalline selenium reacts with organic gas molecules with high sensitivity at room temperature without being influenced by humidity, and the magnitude of change of the value of the current flowing at a fixed voltage varies depending on the kind of an organic gas to be sensed.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: September 15, 2015
    Assignee: Kake Educational Institution
    Inventors: Norio Akiyama, Tsukio Ohtani
  • Publication number: 20120266658
    Abstract: The invention provides a gas sensitive material made from microcrystalline selenium (preferably selenium nanowire) and a gas sensor having an element structure wherein the gas sensitive material is disposed between two electrodes. The invention allows for the kind of organic gas to be distinguished, because microcrystalline selenium reacts with organic gas molecules with high sensitivity at room temperature without being influenced by humidity, and the magnitude of change of the value of the current flowing at a fixed voltage varies depending on the kind of an organic gas to be sensed.
    Type: Application
    Filed: November 4, 2010
    Publication date: October 25, 2012
    Applicant: KAKE EDUCATIONAL INSTITUTION
    Inventors: Norio Akiyama, Tsukio Ohtani
  • Patent number: 6104624
    Abstract: Buck-boost type or buck type chopper circuits and transistors are employed as inverters (IV1, IV2) and power synchronizing switches (SW1, SW2), respectively. A PWM signal is applied to transistors of the chopper circuits to convert DC voltage generated by solar cells (DC1, DC2) into positive and negative half-wave AC voltages for an AC power supply (AC1). The inverters (IV1, IV2) output the AC voltages from their AC output terminals on alternate half cycles thereby to cause backflow of power. The power synchronizing switches (SW1, SW2) performs not only the function of transmitting the half-wave AC voltages generated by the inverters (IV1, IV2) to the AC power supply (AC1) in accordance with the AC cycle of the AC power supply (AC1), but also the function of, when one of the inverters is in operation, insulating the other from the AC power supply (AC1).
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: August 15, 2000
    Assignees: Mitsubishi Denki Kabushiki Kaisha, Kake Educational Institution
    Inventors: Hideo Iwamoto, Takahiko Iida