Abstract: Synthetic blood substitutes and methods for making them. A lipid-amphiphile blood-substitute precursor compound having a hydrophobic fatty acid/acyl moiety, a hydrophilic head moiety including a phosphate group, and a pH responsive moiety. The lipid-amphiphile precursor is configured to self-assemble from a solution mixture of phospholipid and cholesterol in the presence of hemoglobin and an allosteric effector into a hybrid-vesicle resulting from the combined self-assembly of both the amphiphilic lipid-oligomer and the lipids into an advanced vesicular structure containing a hemoglobin/allosteric effector payload.
Type:
Grant
Filed:
April 23, 2021
Date of Patent:
March 25, 2025
Assignee:
KaloCyte, Inc.
Inventors:
Dipanjan Pan, Allan Doctor, Philip C. Spinella
Abstract: Bait and capture methods and compositions for removing bio-synthetic nano-particles from body fluids. Bio-synthetic nano-particles are baited with one-half of a bait and capture complex and lyophilized. The baited bio-synthetic nano-particle is reconstituted and administered to a subject for diagnostic or therapeutic purposes. To remove the bio-synthetic nano-particle from the body, the body fluid containing the baited bio-synthetic nano-article is contacted with the capture portion of the bait and capture complex. The body fluid from which the bio-synthetic nano-particles have been removed may be returned to the subject.
Type:
Grant
Filed:
March 11, 2022
Date of Patent:
December 10, 2024
Assignees:
KaloCyte, Inc., University of Maryland, Baltimore, University of Maryland, Baltimore County
Inventors:
Dipanjan Pan, Allan Doctor, Nivesh Mittal