Abstract: Provided is a method that enables industrially efficient production of an esterified polysaccharide product. A method for producing an esterified polysaccharide product, the method including reacting a polysaccharide-containing biomass, a basic ionic liquid with a pKa of a conjugate acid of an anion from 2 to 19 as a calculated value in a vacuum, and an esterifying agent using a kneader equipped with a shear force application mechanism. A cation constituting the basic ionic liquid is preferably one selected from the group consisting of an imidazolium cation, a pyridinium cation, and a tetraalkylammonium cation.

Abstract: A production method for a low molecular weight polymer suitable for a melt-blown non-woven fabric and a production device for melt-blown non-woven fabric, with which a high molecular weight polymer can be reduced in molecular weight by applying a shear force to the high molecular weight polymer without adding an additive. The low molecular weight polymer and the melt-blown non-woven fabric are produced using a continuous high shearing device that applies a shear force to the high molecular weight polymer serving as a raw material by rotation of a screw body to reduce the molecular weight of the high molecular weight polymer so as to obtain a low molecular weight polymer, and cools the low molecular weight polymer by passing the low molecular weight polymer through a passage arranged in the axial direction inside the screw body.

Abstract: Provided are an organoid having a metastatic property when transplanted into an immunocompetent non-human animal of the same species, a cell strain having a metastatic property when transplanted into an immunocompetent non-human animal of the same species, and a non-human animal including the organoid or the cell strain.

Abstract: A signal acquisition unit of an abnormality detection device for a twin-screw extrusion molding machine, when the twin-screw extrusion molding machine that melts and kneads a fed resin raw material is in operation, acquires an AE output of an AE sensor installed on a surface of a housing of the twin-screw extrusion molding machine. A determination unit determines whether an abnormality occurs in the twin-screw extrusion molding machine, based on a relationship between the AE output and a first threshold and a second threshold.

Abstract: Provided is a composition for promoting secretion of extracellular vesicles, which comprises a compound having a structure of the formula I (wherein each substituent is as defined in the specification), a racemate thereof or a stereoisomer thereof, or a salt thereof, or a compound having a structure of the formula II (wherein each substituent is as defined in the specification), or a stereoisomer thereof, or a salt thereof, or, cucurbitacin, or a stereoisomer thereof, or a salt thereof.

Abstract: An object of the present invention is to provide a method for producing a polysaccharide derivative in which the use of a reagent such as an acid catalyst is not needed and a reaction can be smoothly progressed without causing any side reactions. A method for producing a polysaccharide derivative of the present invention includes a step of dissolving a raw material including a polysaccharide in at least one ionic liquid having an anion which is a non-carboxylate anion and reacting the raw material with an acyl group donor, a conjugate acid of the anion having a pKa of 4 or higher in vacuum.

Abstract: A mount bush includes a tube member, a shaft member disposed coaxially with an axis of the tube member and having a coil, a first liquid chamber disposed at an upper side in an internal space between the tube member and the shaft member, a second liquid chamber in communication with a lower side of the first liquid chamber and containing a magnetic viscoelastic fluid, and a third liquid chamber in communication with a lower side of the second liquid chamber and having a porous body, wherein the coil is disposed such that a magnetic path that passes through the second liquid chamber in an orientation along at least one of an axial direction and a radial direction is formed through electrical conduction.

Abstract: The invention provides a composition for suppressing secretion of extracellular vesicle, which comprises a compound having a structure of the formula II (wherein, each substituent is as defined in the specification), or a pharmaceutically acceptable salt thereof, or a compound having a structure of the formula I (wherein, each substituent is as defined in the specification), or a metal complex thereof, or a pharmaceutically acceptable salt thereof.

Abstract: A mount bush includes a tubular member, a shaft member disposed inside the tubular member coaxially with an axis of the tubular member and including a coil, a permanent magnet provided on at least one of the tubular member and the shaft member, a magnetic viscoelastic fluid filled in an internal space, a first liquid chamber disposed in the internal space at a first side, a second liquid chamber communicating with the first liquid chamber, and a third liquid chamber communicating with the second liquid chamber, wherein the coil is disposed such that a magnetic path passing through the second liquid chamber in an orientation along at least one of the axial direction and the radial direction perpendicular to the axial direction is formed through electrical conduction, and the permanent magnet is disposed such that a magnetizing direction is formed along the magnetic path.

Abstract: The present invention aims to provide a method for producing a trans-polyisoprenoid which can increase trans rubber production. The present invention is directed to a method for producing a trans-polyisoprenoid in vitro, which involves the use of a gene coding for a trans-prenyltransferase (tPT) family protein and further involves the use of rubber particles bound to a protein encoded by the gene, or a method for producing a trans-polyisoprenoid, which includes introducing into a plant a vector including a promotor having a promoter activity that drives laticifer-specific gene expression and a gene coding for a tPT family protein linked to the promotor to express a protein encoded by the gene specifically in laticifers.

Abstract: The present invention aims to provide a method for producing a trans-polyisoprenoid which can increase trans rubber production. The present invention is directed to a method for producing a trans-polyisoprenoid in vitro, which involves the use of a gene coding for a trans-prenyltransferase (tPT) family protein and further involves the use of rubber particles bound to a protein encoded by the gene, or a method for producing a trans-polyisoprenoid, which includes introducing into a plant a vector including a promotor having a promoter activity that drives laticifer-specific gene expression and a gene coding for a tPT family protein linked to the promotor to express a protein encoded by the gene specifically in laticifers.

Abstract: The present invention provides: a marker for determining critical stage kidney disease by using an indicator value based on the amount of D-alanine in the blood or the amount of D-alanine and L-alanine therein; a blood analysis method which uses said marker for patients undergoing surgery or intensive care; and a blood analysis system for determining critical stage kidney disease in patients undergoing surgery or intensive care.

Abstract: It is an object to provide a method for producing a diamond substrate effective for reducing various defects including dislocation defects and a foundation substrate used for the same. This object is achieved by a foundation substrate for forming a diamond film by a chemical vapor deposition method, wherein an off angle is provided to the surface of the foundation substrate with respect to a predetermined crystal plane orientation.

Abstract: The present invention pertains to a pharmaceutical composition for the prevention or treatment of kidney disease, an inflammation inhibitor for the kidneys, an inflammatory cell death inhibitor for the kidneys, or a food for the prevention or improvement of kidney disease, that include D-serine or a derivative thereof. In addition, the present invention pertains to the use of D-serine or a derivative thereof, for the production of a pharmaceutical composition for the prevention or treatment of kidney disease.

Abstract: The present invention pertains to a pharmaceutical composition for the prevention or treatment of kidney disease, a kidney inflammation inhibitor, an inflammatory cell death inhibitor for the kidneys, or a food for the prevention or improvement of kidney disease, that include D-alanine or a derivative thereof. In addition, the present invention pertains to the use of D-alanine or a derivative thereof, for the production of a pharmaceutical composition for the prevention or treatment of kidney disease.

Abstract: A method for manufacturing a diamond substrate, including: a first step of preparing patterned diamond on a foundation surface, a second step of growing diamond from the patterned diamond prepared in the first step to form the diamond in a pattern gap of the patterned diamond prepared in the first step, a third step of removing the patterned diamond prepared in the first step to form a patterned diamond composed of the diamond formed in the second step, and a fourth step of growing diamond from the patterned diamond formed in the third step to form the diamond in a pattern gap of the patterned diamond formed in the third step. There can be provided a method for manufacturing a diamond substrate which can sufficiently suppress dislocation defects, a high-quality diamond substrate, and a freestanding diamond substrate.

Abstract: It is an object of the present invention to obtain a novel composite material excellent in terms of flexibility and thermoformability from a lignocellulosic biomass as a raw material. A composite material, in which some hydroxy groups of a lignocellulosic biomass are esterified, which is characterized in that the esterified portion has short-chain acyl groups containing 2 to 4 carbon atoms and long-chain acyl groups containing 3 to 18 carbon atoms.

Abstract: An engine mount control apparatus that is an active noise vibration control apparatus according to the present disclosure is characterized by being provided with a housing that has an outer core, an inner core that is disposed inside the outer core, and an electromagnetic coil that is positioned between the outer core and the inner core and by a portion between the outer core and the inner core being filled with a magneto-rheological elastomer containing magnetic particles. The present disclosure enables the maintenance of good static load support performance.

Abstract: A method for manufacturing diamond substrate of using source gas containing hydrocarbon gas and hydrogen gas to form diamond crystal on an underlying substrate by CVD method, to form a diamond crystal layer having nitrogen-vacancy centers in at least part of the diamond crystal, nitrogen or nitride gas is mixed in the source gas, wherein the source gas is: 0.005 volume % or more and 6.000 volume % or less of the hydrocarbon gas; 93.500 volume % or more and less than 99.995 volume % of the hydrogen gas; and 5.0×10?5 volume % or more and 5.0×10?1 volume % or less of the nitrogen gas or the nitride gas, and the diamond crystal layer having the nitrogen-vacancy centers is formed. A method for manufacturing a diamond substrate to form an underlying substrate, a diamond crystal having a dense nitrogen-vacancy centers (NVCs) with an orientation of NV axis by performing the CVD.

Abstract: The present invention provides a miniaturized hemagglutinin complex protein having function inhibitory activity against E-cadherin, wherein (a) all or a part of at least HA1 subcomponent, and/or a part of HA3 subcomponent are/is deleted, (b) regions in HA2 and HA3 subcomponents that contribute to binding with E-cadherin are present, and (c) the HA3 subcomponent is derived from Clostridium botulinum type A or type B, and an E-cadherin function inhibitor containing the hemagglutinin complex protein.